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Can we optimise doxorubicin treatment regimens for children with cancer? Pharmacokinetic simulations and a Delphi consensus procedure

BACKGROUND: Despite its cardiotoxicity doxorubicin is widely used for the treatment of paediatric malignancies. Current treatment regimens appear to be suboptimal as treatment strategies vary and do not follow a clear pharmacological rationale. Standardisation of dosing strategies in particular for...

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Detalles Bibliográficos
Autores principales:	Siebel, Christian, Würthwein, Gudrun, Lanvers-Kaminsky, Claudia, André, Nicolas, Berthold, Frank, Castelli, Ilaria, Chastagner, Pascal, Doz, François, English, Martin, Escherich, Gabriele, Frühwald, Michael C., Graf, Norbert, Groll, Andreas H., Ruggiero, Antonio, Hempel, Georg, Boos, Joachim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254632/ https://www.ncbi.nlm.nih.gov/pubmed/32466789 http://dx.doi.org/10.1186/s40360-020-00417-2

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