Artesunate: could be an alternative drug to chloroquine in COVID-19 treatment?

SARS (Severe Acute Respiratory Syndrome Coronavirus)-CV-2 (2019-nCov), which showed up in China in December 2019 and spread all over the world, has becomed a serious health problem. An effective, safe and proven treatment has not yet been found. Chloroquine has been recommended by some authors to be...

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Detalles Bibliográficos
Autores principales: Uzun, Tuğçenur, Toptas, Orcun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254722/
https://www.ncbi.nlm.nih.gov/pubmed/32514287
http://dx.doi.org/10.1186/s13020-020-00336-8
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author Uzun, Tuğçenur
Toptas, Orcun
author_facet Uzun, Tuğçenur
Toptas, Orcun
author_sort Uzun, Tuğçenur
collection PubMed
description SARS (Severe Acute Respiratory Syndrome Coronavirus)-CV-2 (2019-nCov), which showed up in China in December 2019 and spread all over the world, has becomed a serious health problem. An effective, safe and proven treatment has not yet been found. Chloroquine has been recommended by some authors to be used for the treatment of patients infected with this virus however chloroquine may have side effects and drug resistance problems. Artesunate is a semisynthetic derivative of artemisinin, an antimalarial drug. Artesunate was thought to be an effective treatment for covid-19 because of its anti-inflammatory activity, NF-κB (nuclear Factor kappa B)-coronavirus effect and chloroquine-like endocytosis inhibition mechanism.
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spelling pubmed-72547222020-06-07 Artesunate: could be an alternative drug to chloroquine in COVID-19 treatment? Uzun, Tuğçenur Toptas, Orcun Chin Med Commentary SARS (Severe Acute Respiratory Syndrome Coronavirus)-CV-2 (2019-nCov), which showed up in China in December 2019 and spread all over the world, has becomed a serious health problem. An effective, safe and proven treatment has not yet been found. Chloroquine has been recommended by some authors to be used for the treatment of patients infected with this virus however chloroquine may have side effects and drug resistance problems. Artesunate is a semisynthetic derivative of artemisinin, an antimalarial drug. Artesunate was thought to be an effective treatment for covid-19 because of its anti-inflammatory activity, NF-κB (nuclear Factor kappa B)-coronavirus effect and chloroquine-like endocytosis inhibition mechanism. BioMed Central 2020-05-28 /pmc/articles/PMC7254722/ /pubmed/32514287 http://dx.doi.org/10.1186/s13020-020-00336-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Commentary
Uzun, Tuğçenur
Toptas, Orcun
Artesunate: could be an alternative drug to chloroquine in COVID-19 treatment?
title Artesunate: could be an alternative drug to chloroquine in COVID-19 treatment?
title_full Artesunate: could be an alternative drug to chloroquine in COVID-19 treatment?
title_fullStr Artesunate: could be an alternative drug to chloroquine in COVID-19 treatment?
title_full_unstemmed Artesunate: could be an alternative drug to chloroquine in COVID-19 treatment?
title_short Artesunate: could be an alternative drug to chloroquine in COVID-19 treatment?
title_sort artesunate: could be an alternative drug to chloroquine in covid-19 treatment?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254722/
https://www.ncbi.nlm.nih.gov/pubmed/32514287
http://dx.doi.org/10.1186/s13020-020-00336-8
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