Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in captive mountain hares (Lepus timidus) in Germany

BACKGROUND: Rabbit hemorrhagic disease virus (RHDV, Lagovirus europeus GI.1) induces a contagious and highly lethal hemorrhagic disease in rabbits. In 2010 a new genotype of lagovirus (GI.2), emerged in Europe, infecting wild and domestic population of rabbits and hares. CASE PRESENTATION: We descri...

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Autores principales: Buehler, Melanie, Jesse, Sonja T., Kueck, Heike, Lange, Bastian, Koenig, Patricia, Jo, Wendy K., Osterhaus, Albert, Beineke, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254734/
https://www.ncbi.nlm.nih.gov/pubmed/32460756
http://dx.doi.org/10.1186/s12917-020-02386-4
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author Buehler, Melanie
Jesse, Sonja T.
Kueck, Heike
Lange, Bastian
Koenig, Patricia
Jo, Wendy K.
Osterhaus, Albert
Beineke, Andreas
author_facet Buehler, Melanie
Jesse, Sonja T.
Kueck, Heike
Lange, Bastian
Koenig, Patricia
Jo, Wendy K.
Osterhaus, Albert
Beineke, Andreas
author_sort Buehler, Melanie
collection PubMed
description BACKGROUND: Rabbit hemorrhagic disease virus (RHDV, Lagovirus europeus GI.1) induces a contagious and highly lethal hemorrhagic disease in rabbits. In 2010 a new genotype of lagovirus (GI.2), emerged in Europe, infecting wild and domestic population of rabbits and hares. CASE PRESENTATION: We describe the infection with a GI.2 strain, “Bremerhaven-17”, in captive mountain hares (Lepus timidus) in a zoo facility in Germany. Postmortem examination revealed RHD-like lesions including necrotizing hepatitis. RT-qPCR and AG-ELISA confirmed presence of GI.2. Recombination and phylogenetic analysis grouped the identified strain with other GI.2 strains, sharing nucleotide identity of 91–99%. CONCLUSION: Our findings confirm that mountain hares are susceptible to GI.2 infection, due to a past recombination event facilitating virus spillover from sympatric rabbits.
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spelling pubmed-72547342020-06-07 Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in captive mountain hares (Lepus timidus) in Germany Buehler, Melanie Jesse, Sonja T. Kueck, Heike Lange, Bastian Koenig, Patricia Jo, Wendy K. Osterhaus, Albert Beineke, Andreas BMC Vet Res Case Report BACKGROUND: Rabbit hemorrhagic disease virus (RHDV, Lagovirus europeus GI.1) induces a contagious and highly lethal hemorrhagic disease in rabbits. In 2010 a new genotype of lagovirus (GI.2), emerged in Europe, infecting wild and domestic population of rabbits and hares. CASE PRESENTATION: We describe the infection with a GI.2 strain, “Bremerhaven-17”, in captive mountain hares (Lepus timidus) in a zoo facility in Germany. Postmortem examination revealed RHD-like lesions including necrotizing hepatitis. RT-qPCR and AG-ELISA confirmed presence of GI.2. Recombination and phylogenetic analysis grouped the identified strain with other GI.2 strains, sharing nucleotide identity of 91–99%. CONCLUSION: Our findings confirm that mountain hares are susceptible to GI.2 infection, due to a past recombination event facilitating virus spillover from sympatric rabbits. BioMed Central 2020-05-27 /pmc/articles/PMC7254734/ /pubmed/32460756 http://dx.doi.org/10.1186/s12917-020-02386-4 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Buehler, Melanie
Jesse, Sonja T.
Kueck, Heike
Lange, Bastian
Koenig, Patricia
Jo, Wendy K.
Osterhaus, Albert
Beineke, Andreas
Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in captive mountain hares (Lepus timidus) in Germany
title Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in captive mountain hares (Lepus timidus) in Germany
title_full Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in captive mountain hares (Lepus timidus) in Germany
title_fullStr Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in captive mountain hares (Lepus timidus) in Germany
title_full_unstemmed Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in captive mountain hares (Lepus timidus) in Germany
title_short Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in captive mountain hares (Lepus timidus) in Germany
title_sort lagovirus europeus gi.2 (rabbit hemorrhagic disease virus 2) infection in captive mountain hares (lepus timidus) in germany
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254734/
https://www.ncbi.nlm.nih.gov/pubmed/32460756
http://dx.doi.org/10.1186/s12917-020-02386-4
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