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Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples
In a large number of cancer types, treatment selection depends on the presence of specific tumor biomarkers. Due to the dynamic nature of cancer, very often these predictive biomarkers are not uniformly present in all cancer cells. Tumor heterogeneity represents indeed one of the main causes of ther...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254767/ https://www.ncbi.nlm.nih.gov/pubmed/32460897 http://dx.doi.org/10.1186/s13046-020-01601-2 |
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author | Russano, Marco Napolitano, Andrea Ribelli, Giulia Iuliani, Michele Simonetti, Sonia Citarella, Fabrizio Pantano, Francesco Dell’Aquila, Emanuela Anesi, Cecilia Silvestris, Nicola Argentiero, Antonella Solimando, Antonio Vincenzi, Bruno Tonini, Giuseppe Santini, Daniele |
author_facet | Russano, Marco Napolitano, Andrea Ribelli, Giulia Iuliani, Michele Simonetti, Sonia Citarella, Fabrizio Pantano, Francesco Dell’Aquila, Emanuela Anesi, Cecilia Silvestris, Nicola Argentiero, Antonella Solimando, Antonio Vincenzi, Bruno Tonini, Giuseppe Santini, Daniele |
author_sort | Russano, Marco |
collection | PubMed |
description | In a large number of cancer types, treatment selection depends on the presence of specific tumor biomarkers. Due to the dynamic nature of cancer, very often these predictive biomarkers are not uniformly present in all cancer cells. Tumor heterogeneity represents indeed one of the main causes of therapeutic failure, and its decoding remains a major ongoing challenge in the field. Liquid biopsy is the sampling and analysis of non-solid biological tissue often through rapid and non-invasive methods, which allows the assessment in real-time of the evolving landscape of cancer. Samples can be obtained from blood and most other bodily fluids. A blood-based liquid biopsy can capture circulating tumor cells and leukocytes, as well as circulating tumor-derived nucleic acids. In this review, we discuss the current and possibly future applications of blood-based liquid biopsy in oncology, its advantages and its limitations in clinical practice. We specifically focused on its role as a tool to capture tumor heterogeneity in metastatic cancer patients. |
format | Online Article Text |
id | pubmed-7254767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-72547672020-06-07 Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples Russano, Marco Napolitano, Andrea Ribelli, Giulia Iuliani, Michele Simonetti, Sonia Citarella, Fabrizio Pantano, Francesco Dell’Aquila, Emanuela Anesi, Cecilia Silvestris, Nicola Argentiero, Antonella Solimando, Antonio Vincenzi, Bruno Tonini, Giuseppe Santini, Daniele J Exp Clin Cancer Res Review In a large number of cancer types, treatment selection depends on the presence of specific tumor biomarkers. Due to the dynamic nature of cancer, very often these predictive biomarkers are not uniformly present in all cancer cells. Tumor heterogeneity represents indeed one of the main causes of therapeutic failure, and its decoding remains a major ongoing challenge in the field. Liquid biopsy is the sampling and analysis of non-solid biological tissue often through rapid and non-invasive methods, which allows the assessment in real-time of the evolving landscape of cancer. Samples can be obtained from blood and most other bodily fluids. A blood-based liquid biopsy can capture circulating tumor cells and leukocytes, as well as circulating tumor-derived nucleic acids. In this review, we discuss the current and possibly future applications of blood-based liquid biopsy in oncology, its advantages and its limitations in clinical practice. We specifically focused on its role as a tool to capture tumor heterogeneity in metastatic cancer patients. BioMed Central 2020-05-27 /pmc/articles/PMC7254767/ /pubmed/32460897 http://dx.doi.org/10.1186/s13046-020-01601-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Russano, Marco Napolitano, Andrea Ribelli, Giulia Iuliani, Michele Simonetti, Sonia Citarella, Fabrizio Pantano, Francesco Dell’Aquila, Emanuela Anesi, Cecilia Silvestris, Nicola Argentiero, Antonella Solimando, Antonio Vincenzi, Bruno Tonini, Giuseppe Santini, Daniele Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples |
title | Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples |
title_full | Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples |
title_fullStr | Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples |
title_full_unstemmed | Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples |
title_short | Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples |
title_sort | liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254767/ https://www.ncbi.nlm.nih.gov/pubmed/32460897 http://dx.doi.org/10.1186/s13046-020-01601-2 |
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