Cobalt-Catalyzed E-Selective Isomerization of Alkenes with a Phosphine-Amido-Oxazoline Ligand

[Image: see text] An efficient method to access (E)-trisubstituted alkenes is reported via cobalt-catalyzed isomerization of 1,1-disubstituted alkenes using a phosphine-amido-oxazoline ligand. The reaction could also convert mono- and 1,2-disubstituted alkenes to (E)-internal alkenes with benzylic s...

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Detalles Bibliográficos
Autores principales: Liu, Hongmei, Cai, Cheng, Ding, Yanghao, Chen, Jianhui, Liu, Bosheng, Xia, Yuanzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254813/
https://www.ncbi.nlm.nih.gov/pubmed/32478256
http://dx.doi.org/10.1021/acsomega.0c00951
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author Liu, Hongmei
Cai, Cheng
Ding, Yanghao
Chen, Jianhui
Liu, Bosheng
Xia, Yuanzhi
author_facet Liu, Hongmei
Cai, Cheng
Ding, Yanghao
Chen, Jianhui
Liu, Bosheng
Xia, Yuanzhi
author_sort Liu, Hongmei
collection PubMed
description [Image: see text] An efficient method to access (E)-trisubstituted alkenes is reported via cobalt-catalyzed isomerization of 1,1-disubstituted alkenes using a phosphine-amido-oxazoline ligand. The reaction could also convert mono- and 1,2-disubstituted alkenes to (E)-internal alkenes with benzylic selectivity. This protocol is atom-economy and operationally simple and uses readily available starting materials with good functional tolerance. This catalytic system could be scaled up to gram scale smoothly with a catalyst loading of 0.1 mol %.
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spelling pubmed-72548132020-05-29 Cobalt-Catalyzed E-Selective Isomerization of Alkenes with a Phosphine-Amido-Oxazoline Ligand Liu, Hongmei Cai, Cheng Ding, Yanghao Chen, Jianhui Liu, Bosheng Xia, Yuanzhi ACS Omega [Image: see text] An efficient method to access (E)-trisubstituted alkenes is reported via cobalt-catalyzed isomerization of 1,1-disubstituted alkenes using a phosphine-amido-oxazoline ligand. The reaction could also convert mono- and 1,2-disubstituted alkenes to (E)-internal alkenes with benzylic selectivity. This protocol is atom-economy and operationally simple and uses readily available starting materials with good functional tolerance. This catalytic system could be scaled up to gram scale smoothly with a catalyst loading of 0.1 mol %. American Chemical Society 2020-05-12 /pmc/articles/PMC7254813/ /pubmed/32478256 http://dx.doi.org/10.1021/acsomega.0c00951 Text en Copyright © 2020 American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
spellingShingle Liu, Hongmei
Cai, Cheng
Ding, Yanghao
Chen, Jianhui
Liu, Bosheng
Xia, Yuanzhi
Cobalt-Catalyzed E-Selective Isomerization of Alkenes with a Phosphine-Amido-Oxazoline Ligand
title Cobalt-Catalyzed E-Selective Isomerization of Alkenes with a Phosphine-Amido-Oxazoline Ligand
title_full Cobalt-Catalyzed E-Selective Isomerization of Alkenes with a Phosphine-Amido-Oxazoline Ligand
title_fullStr Cobalt-Catalyzed E-Selective Isomerization of Alkenes with a Phosphine-Amido-Oxazoline Ligand
title_full_unstemmed Cobalt-Catalyzed E-Selective Isomerization of Alkenes with a Phosphine-Amido-Oxazoline Ligand
title_short Cobalt-Catalyzed E-Selective Isomerization of Alkenes with a Phosphine-Amido-Oxazoline Ligand
title_sort cobalt-catalyzed e-selective isomerization of alkenes with a phosphine-amido-oxazoline ligand
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254813/
https://www.ncbi.nlm.nih.gov/pubmed/32478256
http://dx.doi.org/10.1021/acsomega.0c00951
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AT chenjianhui cobaltcatalyzedeselectiveisomerizationofalkeneswithaphosphineamidooxazolineligand
AT liubosheng cobaltcatalyzedeselectiveisomerizationofalkeneswithaphosphineamidooxazolineligand
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