Late-onset Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like Episodes (MELAS) Syndrome in a 63-year-old Patient

Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) usually manifests in early life. Clinical hallmarks of the disease are mitochondrial myopathies, encephalopathy with stroke-like episodes, seizures, and lactic acidosis. It rarely manifests in late adulthood. Here...

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Autores principales: Abdullah, Hassan, Shah, Syed, Husain, Humza, Hassan, Furqan, Maqsood, Hamza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255082/
https://www.ncbi.nlm.nih.gov/pubmed/32483512
http://dx.doi.org/10.7759/cureus.7862
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author Abdullah, Hassan
Shah, Syed
Husain, Humza
Hassan, Furqan
Maqsood, Hamza
author_facet Abdullah, Hassan
Shah, Syed
Husain, Humza
Hassan, Furqan
Maqsood, Hamza
author_sort Abdullah, Hassan
collection PubMed
description Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) usually manifests in early life. Clinical hallmarks of the disease are mitochondrial myopathies, encephalopathy with stroke-like episodes, seizures, and lactic acidosis. It rarely manifests in late adulthood. Here we present the case of a 63-year-old female patient who developed recurrent stroke-like symptoms with typical resolving and remitting pattern of findings on imaging. Later on, it was confirmed as a case of MELAS upon genetic analysis.
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spelling pubmed-72550822020-05-31 Late-onset Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like Episodes (MELAS) Syndrome in a 63-year-old Patient Abdullah, Hassan Shah, Syed Husain, Humza Hassan, Furqan Maqsood, Hamza Cureus Genetics Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) usually manifests in early life. Clinical hallmarks of the disease are mitochondrial myopathies, encephalopathy with stroke-like episodes, seizures, and lactic acidosis. It rarely manifests in late adulthood. Here we present the case of a 63-year-old female patient who developed recurrent stroke-like symptoms with typical resolving and remitting pattern of findings on imaging. Later on, it was confirmed as a case of MELAS upon genetic analysis. Cureus 2020-04-27 /pmc/articles/PMC7255082/ /pubmed/32483512 http://dx.doi.org/10.7759/cureus.7862 Text en Copyright © 2020, Abdullah et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Genetics
Abdullah, Hassan
Shah, Syed
Husain, Humza
Hassan, Furqan
Maqsood, Hamza
Late-onset Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like Episodes (MELAS) Syndrome in a 63-year-old Patient
title Late-onset Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like Episodes (MELAS) Syndrome in a 63-year-old Patient
title_full Late-onset Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like Episodes (MELAS) Syndrome in a 63-year-old Patient
title_fullStr Late-onset Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like Episodes (MELAS) Syndrome in a 63-year-old Patient
title_full_unstemmed Late-onset Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like Episodes (MELAS) Syndrome in a 63-year-old Patient
title_short Late-onset Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like Episodes (MELAS) Syndrome in a 63-year-old Patient
title_sort late-onset mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (melas) syndrome in a 63-year-old patient
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255082/
https://www.ncbi.nlm.nih.gov/pubmed/32483512
http://dx.doi.org/10.7759/cureus.7862
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