Potential pathophysiological mechanisms leading to increased COVID-19 susceptibility and severity in obesity

As we are facing worldwide pandemic of COVID-19, we aimed to identify potential pathophysiological mechanisms leading to increased COVID-19 susceptibility and severity in obesity. Special emphasis will be given on increased susceptibility to infections due to obesity-related low-grade chronic inflam...

Descripción completa

Detalles Bibliográficos
Autores principales: Belančić, Andrej, Kresović, Andrea, Rački, Valentino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255205/
https://www.ncbi.nlm.nih.gov/pubmed/32501427
http://dx.doi.org/10.1016/j.obmed.2020.100259
_version_ 1783539688097710080
author Belančić, Andrej
Kresović, Andrea
Rački, Valentino
author_facet Belančić, Andrej
Kresović, Andrea
Rački, Valentino
author_sort Belančić, Andrej
collection PubMed
description As we are facing worldwide pandemic of COVID-19, we aimed to identify potential pathophysiological mechanisms leading to increased COVID-19 susceptibility and severity in obesity. Special emphasis will be given on increased susceptibility to infections due to obesity-related low-grade chronic inflammation, higher expression of angiotensin converting enzyme-2 and pathway-associated components, as well as decreased vitamin D bioavailability, since all of them provide easier ways for the virus to enter into host cells, replicate and stunt adequate immune responses.
format Online
Article
Text
id pubmed-7255205
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-72552052020-05-28 Potential pathophysiological mechanisms leading to increased COVID-19 susceptibility and severity in obesity Belančić, Andrej Kresović, Andrea Rački, Valentino Obes Med Article As we are facing worldwide pandemic of COVID-19, we aimed to identify potential pathophysiological mechanisms leading to increased COVID-19 susceptibility and severity in obesity. Special emphasis will be given on increased susceptibility to infections due to obesity-related low-grade chronic inflammation, higher expression of angiotensin converting enzyme-2 and pathway-associated components, as well as decreased vitamin D bioavailability, since all of them provide easier ways for the virus to enter into host cells, replicate and stunt adequate immune responses. Elsevier Ltd. 2020-09 2020-05-26 /pmc/articles/PMC7255205/ /pubmed/32501427 http://dx.doi.org/10.1016/j.obmed.2020.100259 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Belančić, Andrej
Kresović, Andrea
Rački, Valentino
Potential pathophysiological mechanisms leading to increased COVID-19 susceptibility and severity in obesity
title Potential pathophysiological mechanisms leading to increased COVID-19 susceptibility and severity in obesity
title_full Potential pathophysiological mechanisms leading to increased COVID-19 susceptibility and severity in obesity
title_fullStr Potential pathophysiological mechanisms leading to increased COVID-19 susceptibility and severity in obesity
title_full_unstemmed Potential pathophysiological mechanisms leading to increased COVID-19 susceptibility and severity in obesity
title_short Potential pathophysiological mechanisms leading to increased COVID-19 susceptibility and severity in obesity
title_sort potential pathophysiological mechanisms leading to increased covid-19 susceptibility and severity in obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255205/
https://www.ncbi.nlm.nih.gov/pubmed/32501427
http://dx.doi.org/10.1016/j.obmed.2020.100259
work_keys_str_mv AT belancicandrej potentialpathophysiologicalmechanismsleadingtoincreasedcovid19susceptibilityandseverityinobesity
AT kresovicandrea potentialpathophysiologicalmechanismsleadingtoincreasedcovid19susceptibilityandseverityinobesity
AT rackivalentino potentialpathophysiologicalmechanismsleadingtoincreasedcovid19susceptibilityandseverityinobesity

Ejemplares similares