Revealing the selective mechanisms of inhibitors to PARP-1 and PARP-2 via multiple computational methods

BACKGROUND: Research has shown that Poly-ADP-ribose polymerases 1 (PARP-1) is a potential therapeutic target in the clinical treatment of breast cancer. An increasing number of studies have focused on the development of highly selective inhibitors that target PARP-1 over PARP-2, its closest isoform,...

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Detalles Bibliográficos
Autores principales: Hu, Hongye, Chen, Buran, Zheng, Danni, Huang, Guanli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255342/
https://www.ncbi.nlm.nih.gov/pubmed/32509471
http://dx.doi.org/10.7717/peerj.9241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255342/
https://www.ncbi.nlm.nih.gov/pubmed/32509471
http://dx.doi.org/10.7717/peerj.9241

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