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Revealing the selective mechanisms of inhibitors to PARP-1 and PARP-2 via multiple computational methods
BACKGROUND: Research has shown that Poly-ADP-ribose polymerases 1 (PARP-1) is a potential therapeutic target in the clinical treatment of breast cancer. An increasing number of studies have focused on the development of highly selective inhibitors that target PARP-1 over PARP-2, its closest isoform,...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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PeerJ Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255342/ https://www.ncbi.nlm.nih.gov/pubmed/32509471 http://dx.doi.org/10.7717/peerj.9241 |