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Prognostic Factors among Brain Metastases in Newly Diagnosed Ovary Cancer: A Large Real-world Study

Background: Population-based data on the prognosis of brain metastases at initial diagnosis of ovary cancer (OCBM) are currently lacking. Besides, the effective treatment for OCBM patients is still controversial now. The study aimed to explore the prognostic factors among OCBM. Methods: We retrospec...

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Autores principales: Xi, Sujuan, Li, Zaiyi, Guo, Quan, Lin, Wenjing, Liang, Xiaokun, Ma, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255353/
https://www.ncbi.nlm.nih.gov/pubmed/32489480
http://dx.doi.org/10.7150/jca.44494
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author Xi, Sujuan
Li, Zaiyi
Guo, Quan
Lin, Wenjing
Liang, Xiaokun
Ma, Lin
author_facet Xi, Sujuan
Li, Zaiyi
Guo, Quan
Lin, Wenjing
Liang, Xiaokun
Ma, Lin
author_sort Xi, Sujuan
collection PubMed
description Background: Population-based data on the prognosis of brain metastases at initial diagnosis of ovary cancer (OCBM) are currently lacking. Besides, the effective treatment for OCBM patients is still controversial now. The study aimed to explore the prognostic factors among OCBM. Methods: We retrospectively reviewed the OCBM patients from the Surveillance, Epidemiology, and End Result (SEER) database of the National Cancer Institute to investigate predictors of the presence of OCBM and its' prognostic factors related to all-cause mortality. We employed multivariable logistic and Cox regression analysis. Furthermore, to minimize the impact of potential confounding factors, we conducted a 1:1 propensity score matching (PSM) analysis. Results: A total of 29,512 cases of OC patients entered into the study, including 89 patients with brain metastases of ovarian cancer, which accounted for 0.30% of the entire cohort and 12.02% of the metastatic disease subset. We identified eight factors, including laterality, histology, surgery, radiotherapy, chemotherapy, and extracranial metastatic sites to bone, liver, and lung, as predictors of OCBM based on multivariable logistic regression among the entire cohort. The median survival time of OCBM was 2.0 months, and the interquartile range was 2.0-10.0 mo. The patients who received comprehensive treatment had better prognosis. Based on the multivariable Cox model, marital status, surgery, chemotherapy, and extensive therapy (including RSC, SC, and RC) were identified as predictors of OS. Besides, a new factor (brain metastasis) was identified by 1:1 PSM -based multiple Cox regression, apart from the above prognostic factors for OS. Conclusions: This study provided a population-based estimate of the proportion and prognosis for newly diagnosed ovary cancer with brain metastases. These findings may add materials to guidelines for preliminary screening and optimal treatment of OCBM patients.
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spelling pubmed-72553532020-06-01 Prognostic Factors among Brain Metastases in Newly Diagnosed Ovary Cancer: A Large Real-world Study Xi, Sujuan Li, Zaiyi Guo, Quan Lin, Wenjing Liang, Xiaokun Ma, Lin J Cancer Research Paper Background: Population-based data on the prognosis of brain metastases at initial diagnosis of ovary cancer (OCBM) are currently lacking. Besides, the effective treatment for OCBM patients is still controversial now. The study aimed to explore the prognostic factors among OCBM. Methods: We retrospectively reviewed the OCBM patients from the Surveillance, Epidemiology, and End Result (SEER) database of the National Cancer Institute to investigate predictors of the presence of OCBM and its' prognostic factors related to all-cause mortality. We employed multivariable logistic and Cox regression analysis. Furthermore, to minimize the impact of potential confounding factors, we conducted a 1:1 propensity score matching (PSM) analysis. Results: A total of 29,512 cases of OC patients entered into the study, including 89 patients with brain metastases of ovarian cancer, which accounted for 0.30% of the entire cohort and 12.02% of the metastatic disease subset. We identified eight factors, including laterality, histology, surgery, radiotherapy, chemotherapy, and extracranial metastatic sites to bone, liver, and lung, as predictors of OCBM based on multivariable logistic regression among the entire cohort. The median survival time of OCBM was 2.0 months, and the interquartile range was 2.0-10.0 mo. The patients who received comprehensive treatment had better prognosis. Based on the multivariable Cox model, marital status, surgery, chemotherapy, and extensive therapy (including RSC, SC, and RC) were identified as predictors of OS. Besides, a new factor (brain metastasis) was identified by 1:1 PSM -based multiple Cox regression, apart from the above prognostic factors for OS. Conclusions: This study provided a population-based estimate of the proportion and prognosis for newly diagnosed ovary cancer with brain metastases. These findings may add materials to guidelines for preliminary screening and optimal treatment of OCBM patients. Ivyspring International Publisher 2020-05-18 /pmc/articles/PMC7255353/ /pubmed/32489480 http://dx.doi.org/10.7150/jca.44494 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Xi, Sujuan
Li, Zaiyi
Guo, Quan
Lin, Wenjing
Liang, Xiaokun
Ma, Lin
Prognostic Factors among Brain Metastases in Newly Diagnosed Ovary Cancer: A Large Real-world Study
title Prognostic Factors among Brain Metastases in Newly Diagnosed Ovary Cancer: A Large Real-world Study
title_full Prognostic Factors among Brain Metastases in Newly Diagnosed Ovary Cancer: A Large Real-world Study
title_fullStr Prognostic Factors among Brain Metastases in Newly Diagnosed Ovary Cancer: A Large Real-world Study
title_full_unstemmed Prognostic Factors among Brain Metastases in Newly Diagnosed Ovary Cancer: A Large Real-world Study
title_short Prognostic Factors among Brain Metastases in Newly Diagnosed Ovary Cancer: A Large Real-world Study
title_sort prognostic factors among brain metastases in newly diagnosed ovary cancer: a large real-world study
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255353/
https://www.ncbi.nlm.nih.gov/pubmed/32489480
http://dx.doi.org/10.7150/jca.44494
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