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Establishing a prediction model of infection during the intravesical instillation of bladder cancer: a multicenter retrospective study
Objective: To explore the independent risk factors of infection during the intravesical instillation of bladder cancer and establish a prediction model, which may reduce probability of infection for bladder cancer patients. Material and Methods: 533 patients with newly discovered NMIBC at two hospit...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255357/ https://www.ncbi.nlm.nih.gov/pubmed/32489451 http://dx.doi.org/10.7150/jca.45055 |
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author | Chen, Song Yang, Yun Luo, Ziyi Deng, Haiqing Peng, Tiancheng Guo, Zhongqiang |
author_facet | Chen, Song Yang, Yun Luo, Ziyi Deng, Haiqing Peng, Tiancheng Guo, Zhongqiang |
author_sort | Chen, Song |
collection | PubMed |
description | Objective: To explore the independent risk factors of infection during the intravesical instillation of bladder cancer and establish a prediction model, which may reduce probability of infection for bladder cancer patients. Material and Methods: 533 patients with newly discovered NMIBC at two hospitals from January 2017 to December 2019 were enrolled in this study. The patients were divided into “infection positive group” and “infection negative group”. The clinical data of the two groups were analyzed by logistic regression analyses. Nomogram was generated and ROC curve, calibration curve were structured to assess the accuracy of nomogram. An independent cohort included 174 patients from another hospital validated the nomogram prediction model. Results: Of 533 patients, 185 patients had an infection. Univariate and multivariate logistic regression analyses showed diabetes mellitus, hemiplegia, patients without antibiotics and perfusion frequency (≥2 times/month) were the independent risk factors. AUC of the ROC was 0.858 (0.762-0.904). The nomogram could predict the probability of infection during the intravesical instillation of bladder tumor calibration curve showed good agreement. The external data validation gained good sensitivity and specificity, which indicated that the nomogram had great value of prediction. Conclusions: Individualized prediction of the probability of infection may reduce the incidence of infection by argeted preventive measures. |
format | Online Article Text |
id | pubmed-7255357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-72553572020-06-01 Establishing a prediction model of infection during the intravesical instillation of bladder cancer: a multicenter retrospective study Chen, Song Yang, Yun Luo, Ziyi Deng, Haiqing Peng, Tiancheng Guo, Zhongqiang J Cancer Research Paper Objective: To explore the independent risk factors of infection during the intravesical instillation of bladder cancer and establish a prediction model, which may reduce probability of infection for bladder cancer patients. Material and Methods: 533 patients with newly discovered NMIBC at two hospitals from January 2017 to December 2019 were enrolled in this study. The patients were divided into “infection positive group” and “infection negative group”. The clinical data of the two groups were analyzed by logistic regression analyses. Nomogram was generated and ROC curve, calibration curve were structured to assess the accuracy of nomogram. An independent cohort included 174 patients from another hospital validated the nomogram prediction model. Results: Of 533 patients, 185 patients had an infection. Univariate and multivariate logistic regression analyses showed diabetes mellitus, hemiplegia, patients without antibiotics and perfusion frequency (≥2 times/month) were the independent risk factors. AUC of the ROC was 0.858 (0.762-0.904). The nomogram could predict the probability of infection during the intravesical instillation of bladder tumor calibration curve showed good agreement. The external data validation gained good sensitivity and specificity, which indicated that the nomogram had great value of prediction. Conclusions: Individualized prediction of the probability of infection may reduce the incidence of infection by argeted preventive measures. Ivyspring International Publisher 2020-04-27 /pmc/articles/PMC7255357/ /pubmed/32489451 http://dx.doi.org/10.7150/jca.45055 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Chen, Song Yang, Yun Luo, Ziyi Deng, Haiqing Peng, Tiancheng Guo, Zhongqiang Establishing a prediction model of infection during the intravesical instillation of bladder cancer: a multicenter retrospective study |
title | Establishing a prediction model of infection during the intravesical instillation of bladder cancer: a multicenter retrospective study |
title_full | Establishing a prediction model of infection during the intravesical instillation of bladder cancer: a multicenter retrospective study |
title_fullStr | Establishing a prediction model of infection during the intravesical instillation of bladder cancer: a multicenter retrospective study |
title_full_unstemmed | Establishing a prediction model of infection during the intravesical instillation of bladder cancer: a multicenter retrospective study |
title_short | Establishing a prediction model of infection during the intravesical instillation of bladder cancer: a multicenter retrospective study |
title_sort | establishing a prediction model of infection during the intravesical instillation of bladder cancer: a multicenter retrospective study |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255357/ https://www.ncbi.nlm.nih.gov/pubmed/32489451 http://dx.doi.org/10.7150/jca.45055 |
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