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Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma
A systematic study of the stability of a set of cephalosporins in mouse plasma reveals that cephalosporins lacking an acidic moiety at C-2 may be vulnerable to β-lactam cleavage in mouse plasma.
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255492/ https://www.ncbi.nlm.nih.gov/pubmed/30903100 http://dx.doi.org/10.1038/s41429-019-0167-y |
| _version_ | 1783539742462181376 |
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| author | Zimmerman, Matthew McDonald, Stacey L. Ho-Liang, Hsin-Pin Porubsky, Patrick Nguyen, Quyen Pharr, Cameron W. Perkowski, Andrew J. Smith, Robert Schoenen, Frank J. Gold, Ben S. Zhang, David Nathan, Carl F. Dartois, Véronique Aubé, Jeffrey |
| author_facet | Zimmerman, Matthew McDonald, Stacey L. Ho-Liang, Hsin-Pin Porubsky, Patrick Nguyen, Quyen Pharr, Cameron W. Perkowski, Andrew J. Smith, Robert Schoenen, Frank J. Gold, Ben S. Zhang, David Nathan, Carl F. Dartois, Véronique Aubé, Jeffrey |
| author_sort | Zimmerman, Matthew |
| collection | PubMed |
| description | A systematic study of the stability of a set of cephalosporins in mouse plasma reveals that cephalosporins lacking an acidic moiety at C-2 may be vulnerable to β-lactam cleavage in mouse plasma. |
| format | Online Article Text |
| id | pubmed-7255492 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-72554922020-05-28 Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma Zimmerman, Matthew McDonald, Stacey L. Ho-Liang, Hsin-Pin Porubsky, Patrick Nguyen, Quyen Pharr, Cameron W. Perkowski, Andrew J. Smith, Robert Schoenen, Frank J. Gold, Ben S. Zhang, David Nathan, Carl F. Dartois, Véronique Aubé, Jeffrey J Antibiot (Tokyo) Special Feature: Article A systematic study of the stability of a set of cephalosporins in mouse plasma reveals that cephalosporins lacking an acidic moiety at C-2 may be vulnerable to β-lactam cleavage in mouse plasma. Nature Publishing Group UK 2019-03-22 2019 /pmc/articles/PMC7255492/ /pubmed/30903100 http://dx.doi.org/10.1038/s41429-019-0167-y Text en © The Author(s) 2019 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Special Feature: Article Zimmerman, Matthew McDonald, Stacey L. Ho-Liang, Hsin-Pin Porubsky, Patrick Nguyen, Quyen Pharr, Cameron W. Perkowski, Andrew J. Smith, Robert Schoenen, Frank J. Gold, Ben S. Zhang, David Nathan, Carl F. Dartois, Véronique Aubé, Jeffrey Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma |
| title | Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma |
| title_full | Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma |
| title_fullStr | Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma |
| title_full_unstemmed | Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma |
| title_short | Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma |
| title_sort | effect of c-2 substitution on the stability of non-traditional cephalosporins in mouse plasma |
| topic | Special Feature: Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255492/ https://www.ncbi.nlm.nih.gov/pubmed/30903100 http://dx.doi.org/10.1038/s41429-019-0167-y |
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