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Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma

A systematic study of the stability of a set of cephalosporins in mouse plasma reveals that cephalosporins lacking an acidic moiety at C-2 may be vulnerable to β-lactam cleavage in mouse plasma.

Detalles Bibliográficos
Autores principales:	Zimmerman, Matthew, McDonald, Stacey L., Ho-Liang, Hsin-Pin, Porubsky, Patrick, Nguyen, Quyen, Pharr, Cameron W., Perkowski, Andrew J., Smith, Robert, Schoenen, Frank J., Gold, Ben S., Zhang, David, Nathan, Carl F., Dartois, Véronique, Aubé, Jeffrey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Special Feature: Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255492/ https://www.ncbi.nlm.nih.gov/pubmed/30903100 http://dx.doi.org/10.1038/s41429-019-0167-y

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