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Crystal structure of the catalytic C‐lobe of the HECT‐type ubiquitin ligase E6AP

The HECT‐type ubiquitin ligase E6AP (UBE3A) is critically involved in several neurodevelopmental disorders and human papilloma virus‐induced cervical tumorigenesis; the structural mechanisms underlying the activity of this crucial ligase, however, are incompletely understood. Here, we report a cryst...

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Detalles Bibliográficos
Autores principales:	Ries, Lena K., Liess, Anna K. L., Feiler, Christian G., Spratt, Donald E., Lowe, Edward D., Lorenz, Sonja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2020
Materias:	Protein Structure Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255509/ https://www.ncbi.nlm.nih.gov/pubmed/31994269 http://dx.doi.org/10.1002/pro.3832

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