Genetic Heterogeneity of Australian Candida auris Isolates: Insights From a Nonoutbreak Setting Using Whole-Genome Sequencing

Whole-genome sequencing clustered Australian Candida auris isolates from sporadic cases within clade III. Case isolates were genomically distinct; however, unexpectedly, those from 1 case comprised 2 groups separated by >60 single nucleotide polymorphisms (SNPs) with no isolate being identical, i...

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Detalles Bibliográficos
Autores principales: Biswas, Chayanika, Wang, Qinning, van Hal, Sebastiaan J, Eyre, David W, Hudson, Bernard, Halliday, Catriona L, Mazsewska, Krystyna, Kizny Gordon, Alice, Lee, Andie, Irinyi, Laszlo, Heath, Christopher H, Chakrabarti, Arunaloke, Govender, Nelesh P, Meyer, Wieland, Sintchenko, Vitali, Chen, Sharon C-A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255648/
https://www.ncbi.nlm.nih.gov/pubmed/32500091
http://dx.doi.org/10.1093/ofid/ofaa158
Descripción
Sumario:Whole-genome sequencing clustered Australian Candida auris isolates from sporadic cases within clade III. Case isolates were genomically distinct; however, unexpectedly, those from 1 case comprised 2 groups separated by >60 single nucleotide polymorphisms (SNPs) with no isolate being identical, in contrast to outbreaks where isolates from any 1 individual have differed by <3 SNPs. Multidrug resistance was absent. High within-host genetic heterogeneity should be considered when investigating C. auris infections.

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