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Recent advances in understanding the role of leptin in energy homeostasis

The hormone leptin plays a critical role in energy homeostasis, although our overall understanding of acutely changing leptin levels still needs improvement. Several developments allow a fresh look at recent and early data on leptin action. This review highlights select recent publications that are...

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Detalles Bibliográficos
Autores principales: Münzberg, Heike, Singh, Prachi, Heymsfield, Steven B., Yu, Sangho, Morrison, Christopher D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255681/
https://www.ncbi.nlm.nih.gov/pubmed/32518627
http://dx.doi.org/10.12688/f1000research.24260.1
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author Münzberg, Heike
Singh, Prachi
Heymsfield, Steven B.
Yu, Sangho
Morrison, Christopher D.
author_facet Münzberg, Heike
Singh, Prachi
Heymsfield, Steven B.
Yu, Sangho
Morrison, Christopher D.
author_sort Münzberg, Heike
collection PubMed
description The hormone leptin plays a critical role in energy homeostasis, although our overall understanding of acutely changing leptin levels still needs improvement. Several developments allow a fresh look at recent and early data on leptin action. This review highlights select recent publications that are relevant for understanding the role played by dynamic changes in circulating leptin levels. We further discuss the relevance for our current understanding of leptin signaling in central neuronal feeding and energy expenditure circuits and highlight cohesive and discrepant findings that need to be addressed in future studies to understand how leptin couples with physiological adaptations of food intake and energy expenditure.
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spelling pubmed-72556812020-06-08 Recent advances in understanding the role of leptin in energy homeostasis Münzberg, Heike Singh, Prachi Heymsfield, Steven B. Yu, Sangho Morrison, Christopher D. F1000Res Review The hormone leptin plays a critical role in energy homeostasis, although our overall understanding of acutely changing leptin levels still needs improvement. Several developments allow a fresh look at recent and early data on leptin action. This review highlights select recent publications that are relevant for understanding the role played by dynamic changes in circulating leptin levels. We further discuss the relevance for our current understanding of leptin signaling in central neuronal feeding and energy expenditure circuits and highlight cohesive and discrepant findings that need to be addressed in future studies to understand how leptin couples with physiological adaptations of food intake and energy expenditure. F1000 Research Limited 2020-05-27 /pmc/articles/PMC7255681/ /pubmed/32518627 http://dx.doi.org/10.12688/f1000research.24260.1 Text en Copyright: © 2020 Münzberg H et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Münzberg, Heike
Singh, Prachi
Heymsfield, Steven B.
Yu, Sangho
Morrison, Christopher D.
Recent advances in understanding the role of leptin in energy homeostasis
title Recent advances in understanding the role of leptin in energy homeostasis
title_full Recent advances in understanding the role of leptin in energy homeostasis
title_fullStr Recent advances in understanding the role of leptin in energy homeostasis
title_full_unstemmed Recent advances in understanding the role of leptin in energy homeostasis
title_short Recent advances in understanding the role of leptin in energy homeostasis
title_sort recent advances in understanding the role of leptin in energy homeostasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255681/
https://www.ncbi.nlm.nih.gov/pubmed/32518627
http://dx.doi.org/10.12688/f1000research.24260.1
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