A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans

piRNAs play a critical role in the regulation of transposons and other germline genes. In Caenorhabditis elegans, regulation of piRNA target genes is mediated by the mutator complex, which synthesizes high levels of siRNAs through the activity of an RNA-dependent RNA polymerase. However, the steps b...

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Detalles Bibliográficos
Autores principales: Manage, Kevin I, Rogers, Alicia K, Wallis, Dylan C, Uebel, Celja J, Anderson, Dorian C, Nguyen, Dieu An H, Arca, Katerina, Brown, Kristen C, Cordeiro Rodrigues, Ricardo J, de Albuquerque, Bruno FM, Ketting, René F, Montgomery, Taiowa A, Phillips, Carolyn Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255803/
https://www.ncbi.nlm.nih.gov/pubmed/32338603
http://dx.doi.org/10.7554/eLife.56731

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