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Cerebral Venous Sinus Thrombosis Associated with Dutasteride Use

Cerebral venous thrombosis (CVT) is an uncommon cause of stroke that mainly affects young adults with known risk factors of prothrombotic conditions, pregnancy, infection, malignancy, and drugs. Dutasteride is a 5α-reductase inhibitor that is used for benign prostate hypertrophy and androgenetic alo...

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Autores principales: Choi, Bo Kyu, Cheon, Kyeongyeol, Cho, Bang-Hoon, Jung, Jae Wook, Lee, Kyung-Yul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255996/
https://www.ncbi.nlm.nih.gov/pubmed/32469180
http://dx.doi.org/10.3349/ymj.2020.61.6.553
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author Choi, Bo Kyu
Cheon, Kyeongyeol
Cho, Bang-Hoon
Jung, Jae Wook
Lee, Kyung-Yul
author_facet Choi, Bo Kyu
Cheon, Kyeongyeol
Cho, Bang-Hoon
Jung, Jae Wook
Lee, Kyung-Yul
author_sort Choi, Bo Kyu
collection PubMed
description Cerebral venous thrombosis (CVT) is an uncommon cause of stroke that mainly affects young adults with known risk factors of prothrombotic conditions, pregnancy, infection, malignancy, and drugs. Dutasteride is a 5α-reductase inhibitor that is used for benign prostate hypertrophy and androgenetic alopecia. To date, CVT caused by dutasteride use has not been reported. A 25-year-old male presented with headache and diplopia. He had taken 0.5 mg of dutasteride every other day for 9 months to treat alopecia. A headache developed 7 months after he started taking medication, and horizontal diplopia occurred 1 month after the onset of headache. Fundus examination showed bilateral papilledema. Brain magnetic resonance imaging showed thrombosis in the left sigmoid and transverse sinuses. Headache and diplopia improved after discontinuing dutasteride and starting anticoagulation. The results from this case report indicated dutasteride as a potential cause of CVT. Presumably, the increased estrogen level due to dutasteride use caused the formation of a thrombus.
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spelling pubmed-72559962020-06-08 Cerebral Venous Sinus Thrombosis Associated with Dutasteride Use Choi, Bo Kyu Cheon, Kyeongyeol Cho, Bang-Hoon Jung, Jae Wook Lee, Kyung-Yul Yonsei Med J Case Report Cerebral venous thrombosis (CVT) is an uncommon cause of stroke that mainly affects young adults with known risk factors of prothrombotic conditions, pregnancy, infection, malignancy, and drugs. Dutasteride is a 5α-reductase inhibitor that is used for benign prostate hypertrophy and androgenetic alopecia. To date, CVT caused by dutasteride use has not been reported. A 25-year-old male presented with headache and diplopia. He had taken 0.5 mg of dutasteride every other day for 9 months to treat alopecia. A headache developed 7 months after he started taking medication, and horizontal diplopia occurred 1 month after the onset of headache. Fundus examination showed bilateral papilledema. Brain magnetic resonance imaging showed thrombosis in the left sigmoid and transverse sinuses. Headache and diplopia improved after discontinuing dutasteride and starting anticoagulation. The results from this case report indicated dutasteride as a potential cause of CVT. Presumably, the increased estrogen level due to dutasteride use caused the formation of a thrombus. Yonsei University College of Medicine 2020-06-01 2020-05-25 /pmc/articles/PMC7255996/ /pubmed/32469180 http://dx.doi.org/10.3349/ymj.2020.61.6.553 Text en © Copyright: Yonsei University College of Medicine 2020 https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Choi, Bo Kyu
Cheon, Kyeongyeol
Cho, Bang-Hoon
Jung, Jae Wook
Lee, Kyung-Yul
Cerebral Venous Sinus Thrombosis Associated with Dutasteride Use
title Cerebral Venous Sinus Thrombosis Associated with Dutasteride Use
title_full Cerebral Venous Sinus Thrombosis Associated with Dutasteride Use
title_fullStr Cerebral Venous Sinus Thrombosis Associated with Dutasteride Use
title_full_unstemmed Cerebral Venous Sinus Thrombosis Associated with Dutasteride Use
title_short Cerebral Venous Sinus Thrombosis Associated with Dutasteride Use
title_sort cerebral venous sinus thrombosis associated with dutasteride use
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255996/
https://www.ncbi.nlm.nih.gov/pubmed/32469180
http://dx.doi.org/10.3349/ymj.2020.61.6.553
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