Cargando…

Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth

Pancreatic ductal adenocarcinoma (PDAC) is well-known for inefficient early diagnosis, with most patients diagnosed at advanced stages. Increasing evidence indicates that elevated plasma levels of branched-chain amino acids (BCAAs) are associated with an increased risk of pancreatic cancer. Branched...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lei, Ming-Zhu, Li, Xu-Xu, Zhang, Ye, Li, Jin-Tao, Zhang, Fan, Wang, Yi-Ping, Yin, Miao, Qu, Jia, Lei, Qun-Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256045/ https://www.ncbi.nlm.nih.gov/pubmed/32467562 http://dx.doi.org/10.1038/s41392-020-0168-0

Ejemplares similares

The Critical Role of the Branched Chain Amino Acids (BCAAs) Catabolism-Regulating Enzymes, Branched-Chain Aminotransferase (BCAT) and Branched-Chain α-Keto Acid Dehydrogenase (BCKD), in Human Pathophysiology
por: Dimou, Aikaterini, et al.
Publicado: (2022)

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance
por: Zhou, Meiyi, et al.
Publicado: (2019)

BCAA Catabolic Defect Alters Glucose Metabolism in Lean Mice
por: Wang, Ji, et al.
Publicado: (2019)

Malignant manipulaTORs of metabolism: suppressing BCAA catabolism to enhance mTORC1 activity
por: Ericksen, Russell E., et al.
Publicado: (2019)

Phosphorylation of BCKDK of BCAA catabolism at Y246 by Src promotes metastasis of colorectal cancer
por: Tian, Qin, et al.
Publicado: (2020)

Dataset reporting BCKDK interference in a BCAA-catabolism restricted environment
por: Bravo-Alonso, I., et al.
Publicado: (2016)

BCKDK of BCAA Catabolism Cross-talking With the MAPK Pathway Promotes Tumorigenesis of Colorectal Cancer
por: Xue, Peipei, et al.
Publicado: (2017)

Diet high in branched-chain amino acid promotes PDAC development by USP1-mediated BCAT2 stabilization
por: Li, Jin-Tao, et al.
Publicado: (2021)

Evaluation of therapeutic strategies targeting BCAA catabolism using a systems pharmacology model
por: Voronova, Veronika, et al.
Publicado: (2022)

Nuclear Translocation of LDHA Promotes the Catabolism of BCAAs to Sustain GBM Cell Proliferation through the TxN Antioxidant Pathway
por: Li, Zhujun, et al.
Publicado: (2023)

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44
por: Yoneshiro, Takeshi, et al.
Publicado: (2019)

Ruscogenin Alleviates Myocardial Ischemia-Induced Ferroptosis through the Activation of BCAT1/BCAT2
por: Fu, Fei, et al.
Publicado: (2022)

A cell-autonomous mechanism regulates BCAA catabolism in white adipocytes and systemic metabolic balance
por: Aguillard, Ashley M., et al.
Publicado: (2023)

Elevated BCAA Suppresses the Development and Metastasis of Breast Cancer
por: Chi, Rui, et al.
Publicado: (2022)

PPARβ/δ Agonism with GW501516 Increases Myotube PGC-1α Content and Reduces BCAA Media Content Independent of Changes in BCAA Catabolic Enzyme Expression
por: Rivera, Caroline N., et al.
Publicado: (2023)

A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes
por: Vanweert, Froukje, et al.
Publicado: (2022)

Loss of BCAA catabolism enhances Rab1A-mTORC1 signaling activity and promotes tumor proliferation in NSCLC
por: Xue, Meiting, et al.
Publicado: (2023)

Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis
por: Lu, Qing-Bo, et al.
Publicado: (2023)

Serum Branch Chain Amino Acids (BCAAs) Are Elevated Due to Decreased Catabolism in Patients With Ketosis-Prone Diabetes at the Time of Presentation With DKA
por: Hsu, Jean Wei, et al.
Publicado: (2021)

P2X1 enhances leukemogenesis through PBX3-BCAT1 pathways
por: He, Xiaoxiao, et al.
Publicado: (2022)

Data mining of the expression and regulatory role of BCAT1 in hepatocellular carcinoma
por: Zou, Haifan, et al.
Publicado: (2019)

BCAT1 promotes tumor cell migration and invasion in hepatocellular carcinoma
por: Xu, Meng, et al.
Publicado: (2016)

LINC00963 Confers Oncogenic Properties in Glioma by Regulating the miR-506/BCAT1 Axis
por: Ye, Feng, et al.
Publicado: (2020)

A higher bacterial inward BCAA transport driven by Faecalibacterium prausnitzii is associated with lower serum levels of BCAA in early adolescents
por: Moran-Ramos, Sofia, et al.
Publicado: (2021)

Differential expression of the BCAT isoforms between breast cancer subtypes
por: Shafei, Mai Ahmed, et al.
Publicado: (2020)

SPOP suppresses pancreatic cancer progression by promoting the degradation of NANOG
por: Tan, Peng, et al.
Publicado: (2019)

Metabolism remodeling in pancreatic ductal adenocarcinoma
por: Li, Jin-Tao, et al.
Publicado: (2019)

Impaired expression of BCAT1 relates to muscle atrophy of mouse model of sarcopenia
por: Ouyang, Hui, et al.
Publicado: (2022)

BCAT1 decreases the sensitivity of cancer cells to cisplatin by regulating mTOR-mediated autophagy via branched-chain amino acid metabolism
por: Luo, Lifang, et al.
Publicado: (2021)

Cancer progression by reprogrammed BCAA metabolism in myeloid leukemia
por: Hattori, Ayuna, et al.
Publicado: (2017)

Gentamicin Induced Microbiome Adaptations Associate With Increased BCAA Levels and Enhance Severity of Influenza Infection
por: Sun, Yakun, et al.
Publicado: (2021)

Reciprocal control of lncRNA-BCAT1 and β-catenin pathway reveals lncRNA-BCAT1 long non-coding RNA acts as a tumor suppressor in colorectal cancer
por: Xie, Fei, et al.
Publicado: (2017)

N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes
por: Prokesch, A., et al.
Publicado: (2016)

BCAA insufficiency leads to premature ovarian insufficiency via ceramide‐induced elevation of ROS
por: Guo, Xiao, et al.
Publicado: (2023)

Dietary Branched-Chain Amino Acids (BCAAs) and Risk of Dyslipidemia in a Chinese Population
por: Yu, Lianlong, et al.
Publicado: (2022)

Catabolic protein degradation in marine sediments confined to distinct archaea
por: Yin, Xiuran, et al.
Publicado: (2022)

Flotillin-2 promotes cell proliferation via activating the c-Myc/BCAT1 axis by suppressing miR-33b-5p in nasopharyngeal carcinoma
por: Liu, Rong, et al.
Publicado: (2021)

Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma
por: Kitagawa, Akihiro, et al.
Publicado: (2023)

Catabolism and biotechnological applications of cholesterol degrading bacteria
por: García, J. L., et al.
Publicado: (2012)

Hypercatabolism and Anti-catabolic Therapies in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome
por: Zhang, Jinlin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_l0j07ru1ulhogv0v3areldtq6f