A Review of the Relationship Between CTRP Family and Coronary Artery Disease

PURPOSE OF REVIEW: In recent years, a family of adiponectin paralogs designated as C1q/TNF-related protein (CTRP) has attracted increasing attention. They are inflammatory adipocytokines mostly secreted from epicardial adipose tissue, which modulate the development and prognosis of coronary artery d...

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Autores principales: Si, Yueqiao, Fan, Wenjun, Sun, Lixian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Vascular Biology (J. Hamilton, Section Editor)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256102/
https://www.ncbi.nlm.nih.gov/pubmed/32468164
http://dx.doi.org/10.1007/s11883-020-00840-0
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author Si, Yueqiao
Fan, Wenjun
Sun, Lixian
author_facet Si, Yueqiao
Fan, Wenjun
Sun, Lixian
author_sort Si, Yueqiao
collection PubMed
description PURPOSE OF REVIEW: In recent years, a family of adiponectin paralogs designated as C1q/TNF-related protein (CTRP) has attracted increasing attention. They are inflammatory adipocytokines mostly secreted from epicardial adipose tissue, which modulate the development and prognosis of coronary artery disease (CAD). This review summarizes the pathophysiological roles of individual members of the CTRP superfamily in the development of CAD. RECENT FINDINGS: Recent studies have revealed how members of the CTRP family, CTRP1, CTRP3, CTRP5, CTRP9, CTRP12, and CTRP13, can influence both development and progression of CAD by modulating metabolic pathways, influencing immuno-inflammatory response, and regulating cardiovascular functions. SUMMARY: Research to date has not been sufficient to answer the specific mechanism of the CTRP family in the occurrence and development of CAD. This review explores the evidence of CTRP superfamily regulating different pathophysiology stages of CAD through the immuno-inflammation, glucose and lipid metabolism, and vascular endothelial function.
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spelling pubmed-72561022020-06-16 A Review of the Relationship Between CTRP Family and Coronary Artery Disease Si, Yueqiao Fan, Wenjun Sun, Lixian Curr Atheroscler Rep Vascular Biology (J. Hamilton, Section Editor) PURPOSE OF REVIEW: In recent years, a family of adiponectin paralogs designated as C1q/TNF-related protein (CTRP) has attracted increasing attention. They are inflammatory adipocytokines mostly secreted from epicardial adipose tissue, which modulate the development and prognosis of coronary artery disease (CAD). This review summarizes the pathophysiological roles of individual members of the CTRP superfamily in the development of CAD. RECENT FINDINGS: Recent studies have revealed how members of the CTRP family, CTRP1, CTRP3, CTRP5, CTRP9, CTRP12, and CTRP13, can influence both development and progression of CAD by modulating metabolic pathways, influencing immuno-inflammatory response, and regulating cardiovascular functions. SUMMARY: Research to date has not been sufficient to answer the specific mechanism of the CTRP family in the occurrence and development of CAD. This review explores the evidence of CTRP superfamily regulating different pathophysiology stages of CAD through the immuno-inflammation, glucose and lipid metabolism, and vascular endothelial function. Springer US 2020-05-28 2020 /pmc/articles/PMC7256102/ /pubmed/32468164 http://dx.doi.org/10.1007/s11883-020-00840-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Vascular Biology (J. Hamilton, Section Editor)
Si, Yueqiao
Fan, Wenjun
Sun, Lixian
A Review of the Relationship Between CTRP Family and Coronary Artery Disease
title A Review of the Relationship Between CTRP Family and Coronary Artery Disease
title_full A Review of the Relationship Between CTRP Family and Coronary Artery Disease
title_fullStr A Review of the Relationship Between CTRP Family and Coronary Artery Disease
title_full_unstemmed A Review of the Relationship Between CTRP Family and Coronary Artery Disease
title_short A Review of the Relationship Between CTRP Family and Coronary Artery Disease
title_sort review of the relationship between ctrp family and coronary artery disease
topic Vascular Biology (J. Hamilton, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256102/
https://www.ncbi.nlm.nih.gov/pubmed/32468164
http://dx.doi.org/10.1007/s11883-020-00840-0
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