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Cancer Susceptibility Candidate 9 (CASC9): A Novel Targetable Long Noncoding RNA in Cancer Treatment

Based on epidemiological data provided by the World Health Organization (2018), cancer is the second most prevalent cause of death worldwide. Several factors are thought to contribute to the high mortality rate in cancer patients, including less-than-optimal diagnostic and therapeutic strategies. Th...

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Detalles Bibliográficos
Autores principales: Sharma, Uttam, Barwal, Tushar Singh, Acharya, Varnali, Tamang, Suraksha, Vasquez, Karen M., Jain, Aklank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256364/
https://www.ncbi.nlm.nih.gov/pubmed/32450549
http://dx.doi.org/10.1016/j.tranon.2020.100774
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author Sharma, Uttam
Barwal, Tushar Singh
Acharya, Varnali
Tamang, Suraksha
Vasquez, Karen M.
Jain, Aklank
author_facet Sharma, Uttam
Barwal, Tushar Singh
Acharya, Varnali
Tamang, Suraksha
Vasquez, Karen M.
Jain, Aklank
author_sort Sharma, Uttam
collection PubMed
description Based on epidemiological data provided by the World Health Organization (2018), cancer is the second most prevalent cause of death worldwide. Several factors are thought to contribute to the high mortality rate in cancer patients, including less-than-optimal diagnostic and therapeutic strategies. Thus, there is an urgent need to identify accurate biomarkers with diagnostic, prognostic, and potential therapeutic applications. In this regard, long noncoding RNAs (lncRNAs) hold immense potential due to their regulatory roles in cancer development and associated cancer hallmarks. Recently, CASC9 transcripts have attracted significant attention due to their altered expression during the pathogenesis of cancer and their apparent contributions to various cancer-associated phenotypes involving a broad spectrum of molecular mechanisms. Here, we have provided an in-depth review describing the known functions of the lncRNA CASC9 in cancer development and progression.
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spelling pubmed-72563642020-06-01 Cancer Susceptibility Candidate 9 (CASC9): A Novel Targetable Long Noncoding RNA in Cancer Treatment Sharma, Uttam Barwal, Tushar Singh Acharya, Varnali Tamang, Suraksha Vasquez, Karen M. Jain, Aklank Transl Oncol Review article Based on epidemiological data provided by the World Health Organization (2018), cancer is the second most prevalent cause of death worldwide. Several factors are thought to contribute to the high mortality rate in cancer patients, including less-than-optimal diagnostic and therapeutic strategies. Thus, there is an urgent need to identify accurate biomarkers with diagnostic, prognostic, and potential therapeutic applications. In this regard, long noncoding RNAs (lncRNAs) hold immense potential due to their regulatory roles in cancer development and associated cancer hallmarks. Recently, CASC9 transcripts have attracted significant attention due to their altered expression during the pathogenesis of cancer and their apparent contributions to various cancer-associated phenotypes involving a broad spectrum of molecular mechanisms. Here, we have provided an in-depth review describing the known functions of the lncRNA CASC9 in cancer development and progression. Neoplasia Press 2020-05-22 /pmc/articles/PMC7256364/ /pubmed/32450549 http://dx.doi.org/10.1016/j.tranon.2020.100774 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review article
Sharma, Uttam
Barwal, Tushar Singh
Acharya, Varnali
Tamang, Suraksha
Vasquez, Karen M.
Jain, Aklank
Cancer Susceptibility Candidate 9 (CASC9): A Novel Targetable Long Noncoding RNA in Cancer Treatment
title Cancer Susceptibility Candidate 9 (CASC9): A Novel Targetable Long Noncoding RNA in Cancer Treatment
title_full Cancer Susceptibility Candidate 9 (CASC9): A Novel Targetable Long Noncoding RNA in Cancer Treatment
title_fullStr Cancer Susceptibility Candidate 9 (CASC9): A Novel Targetable Long Noncoding RNA in Cancer Treatment
title_full_unstemmed Cancer Susceptibility Candidate 9 (CASC9): A Novel Targetable Long Noncoding RNA in Cancer Treatment
title_short Cancer Susceptibility Candidate 9 (CASC9): A Novel Targetable Long Noncoding RNA in Cancer Treatment
title_sort cancer susceptibility candidate 9 (casc9): a novel targetable long noncoding rna in cancer treatment
topic Review article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256364/
https://www.ncbi.nlm.nih.gov/pubmed/32450549
http://dx.doi.org/10.1016/j.tranon.2020.100774
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