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Cancer Susceptibility Candidate 9 (CASC9): A Novel Targetable Long Noncoding RNA in Cancer Treatment
Based on epidemiological data provided by the World Health Organization (2018), cancer is the second most prevalent cause of death worldwide. Several factors are thought to contribute to the high mortality rate in cancer patients, including less-than-optimal diagnostic and therapeutic strategies. Th...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Neoplasia Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256364/ https://www.ncbi.nlm.nih.gov/pubmed/32450549 http://dx.doi.org/10.1016/j.tranon.2020.100774 |
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author | Sharma, Uttam Barwal, Tushar Singh Acharya, Varnali Tamang, Suraksha Vasquez, Karen M. Jain, Aklank |
author_facet | Sharma, Uttam Barwal, Tushar Singh Acharya, Varnali Tamang, Suraksha Vasquez, Karen M. Jain, Aklank |
author_sort | Sharma, Uttam |
collection | PubMed |
description | Based on epidemiological data provided by the World Health Organization (2018), cancer is the second most prevalent cause of death worldwide. Several factors are thought to contribute to the high mortality rate in cancer patients, including less-than-optimal diagnostic and therapeutic strategies. Thus, there is an urgent need to identify accurate biomarkers with diagnostic, prognostic, and potential therapeutic applications. In this regard, long noncoding RNAs (lncRNAs) hold immense potential due to their regulatory roles in cancer development and associated cancer hallmarks. Recently, CASC9 transcripts have attracted significant attention due to their altered expression during the pathogenesis of cancer and their apparent contributions to various cancer-associated phenotypes involving a broad spectrum of molecular mechanisms. Here, we have provided an in-depth review describing the known functions of the lncRNA CASC9 in cancer development and progression. |
format | Online Article Text |
id | pubmed-7256364 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Neoplasia Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-72563642020-06-01 Cancer Susceptibility Candidate 9 (CASC9): A Novel Targetable Long Noncoding RNA in Cancer Treatment Sharma, Uttam Barwal, Tushar Singh Acharya, Varnali Tamang, Suraksha Vasquez, Karen M. Jain, Aklank Transl Oncol Review article Based on epidemiological data provided by the World Health Organization (2018), cancer is the second most prevalent cause of death worldwide. Several factors are thought to contribute to the high mortality rate in cancer patients, including less-than-optimal diagnostic and therapeutic strategies. Thus, there is an urgent need to identify accurate biomarkers with diagnostic, prognostic, and potential therapeutic applications. In this regard, long noncoding RNAs (lncRNAs) hold immense potential due to their regulatory roles in cancer development and associated cancer hallmarks. Recently, CASC9 transcripts have attracted significant attention due to their altered expression during the pathogenesis of cancer and their apparent contributions to various cancer-associated phenotypes involving a broad spectrum of molecular mechanisms. Here, we have provided an in-depth review describing the known functions of the lncRNA CASC9 in cancer development and progression. Neoplasia Press 2020-05-22 /pmc/articles/PMC7256364/ /pubmed/32450549 http://dx.doi.org/10.1016/j.tranon.2020.100774 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review article Sharma, Uttam Barwal, Tushar Singh Acharya, Varnali Tamang, Suraksha Vasquez, Karen M. Jain, Aklank Cancer Susceptibility Candidate 9 (CASC9): A Novel Targetable Long Noncoding RNA in Cancer Treatment |
title | Cancer Susceptibility Candidate 9 (CASC9): A Novel Targetable Long Noncoding RNA in Cancer Treatment |
title_full | Cancer Susceptibility Candidate 9 (CASC9): A Novel Targetable Long Noncoding RNA in Cancer Treatment |
title_fullStr | Cancer Susceptibility Candidate 9 (CASC9): A Novel Targetable Long Noncoding RNA in Cancer Treatment |
title_full_unstemmed | Cancer Susceptibility Candidate 9 (CASC9): A Novel Targetable Long Noncoding RNA in Cancer Treatment |
title_short | Cancer Susceptibility Candidate 9 (CASC9): A Novel Targetable Long Noncoding RNA in Cancer Treatment |
title_sort | cancer susceptibility candidate 9 (casc9): a novel targetable long noncoding rna in cancer treatment |
topic | Review article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256364/ https://www.ncbi.nlm.nih.gov/pubmed/32450549 http://dx.doi.org/10.1016/j.tranon.2020.100774 |
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