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Associations of clinical outcomes and MRI findings in intra-articular administration of autologous adipose-derived stem cells for knee osteoarthritis

INTRODUCTION: Clinical studies of intra-articular injection of mesenchymal stem cells for osteoarthritis (OA) indicate its efficacy. Here, we retrospectively investigated the associations of pretherapeutic magnetic resonance imaging (MRI) findings with the clinical outcomes up to 6 months, after int...

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Autores principales: Higuchi, Junya, Yamagami, Ryota, Matsumoto, Takumi, Terao, Tomohiro, Inoue, Keita, Tsuji, Shinsaku, Maenohara, Yuji, Matsuzaki, Tokio, Chijimatsu, Ryota, Omata, Yasunori, Yano, Fumiko, Tanaka, Sakae, Saito, Taku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society for Regenerative Medicine 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256437/
https://www.ncbi.nlm.nih.gov/pubmed/32490058
http://dx.doi.org/10.1016/j.reth.2020.04.003
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author Higuchi, Junya
Yamagami, Ryota
Matsumoto, Takumi
Terao, Tomohiro
Inoue, Keita
Tsuji, Shinsaku
Maenohara, Yuji
Matsuzaki, Tokio
Chijimatsu, Ryota
Omata, Yasunori
Yano, Fumiko
Tanaka, Sakae
Saito, Taku
author_facet Higuchi, Junya
Yamagami, Ryota
Matsumoto, Takumi
Terao, Tomohiro
Inoue, Keita
Tsuji, Shinsaku
Maenohara, Yuji
Matsuzaki, Tokio
Chijimatsu, Ryota
Omata, Yasunori
Yano, Fumiko
Tanaka, Sakae
Saito, Taku
author_sort Higuchi, Junya
collection PubMed
description INTRODUCTION: Clinical studies of intra-articular injection of mesenchymal stem cells for osteoarthritis (OA) indicate its efficacy. Here, we retrospectively investigated the associations of pretherapeutic magnetic resonance imaging (MRI) findings with the clinical outcomes up to 6 months, after intra-articular administration of adipose-derived stem cells (ASCs) to knee OA patients. METHODS: We first analyzed alterations of the visual analog scale (VAS) and knee injury and osteoarthritis outcome score (KOOS) in 57 knees of 34 patients from whom clinical scores were obtained before ASC therapy, and at 1, 3, and 6 months. Among the patients, we further examined MRI findings of 34 knees of 19 patients whose pretherapeutic MRI data were available. RESULTS: The mean improvement of VAS and KOOS-total during 6 months was 2.6 ± 4.0 (from 6.1 ± 2.5 to 3.5 ± 2.9, P < 0.001) and 10.2 ± 12.4 (from 54.4 ± 12.7 to 64.6 ± 13.8, P < 0.01), respectively. Scales related to pain and symptoms improved earlier than those related to activities of daily living (ADL) and sports/recreation. Improvement of VAS and KOOS-sports/recreation was significantly higher in patients with more severe cartilage lesions. Similarly, osteophyte lesions were associated significantly with improvement of VAS and KOOS-ADL, and BML was associated with KOOS-ADL and KOOS-sports/recreation. CONCLUSIONS: In intra-articular administration of autologous ASCs for knee OA, improvement of VAS and KOOS-sports/recreation was significantly higher in patients with more severe cartilage lesions. Similarly, osteophyte lesions were associated significantly with improvement of VAS and KOOS-ADL, and BML was associated with KOOS-ADL and KOOS-sports/recreation. Clinical studies with larger numbers of patients and various kinds of data are necessary to predict therapeutic effects.
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spelling pubmed-72564372020-06-01 Associations of clinical outcomes and MRI findings in intra-articular administration of autologous adipose-derived stem cells for knee osteoarthritis Higuchi, Junya Yamagami, Ryota Matsumoto, Takumi Terao, Tomohiro Inoue, Keita Tsuji, Shinsaku Maenohara, Yuji Matsuzaki, Tokio Chijimatsu, Ryota Omata, Yasunori Yano, Fumiko Tanaka, Sakae Saito, Taku Regen Ther Review Article INTRODUCTION: Clinical studies of intra-articular injection of mesenchymal stem cells for osteoarthritis (OA) indicate its efficacy. Here, we retrospectively investigated the associations of pretherapeutic magnetic resonance imaging (MRI) findings with the clinical outcomes up to 6 months, after intra-articular administration of adipose-derived stem cells (ASCs) to knee OA patients. METHODS: We first analyzed alterations of the visual analog scale (VAS) and knee injury and osteoarthritis outcome score (KOOS) in 57 knees of 34 patients from whom clinical scores were obtained before ASC therapy, and at 1, 3, and 6 months. Among the patients, we further examined MRI findings of 34 knees of 19 patients whose pretherapeutic MRI data were available. RESULTS: The mean improvement of VAS and KOOS-total during 6 months was 2.6 ± 4.0 (from 6.1 ± 2.5 to 3.5 ± 2.9, P < 0.001) and 10.2 ± 12.4 (from 54.4 ± 12.7 to 64.6 ± 13.8, P < 0.01), respectively. Scales related to pain and symptoms improved earlier than those related to activities of daily living (ADL) and sports/recreation. Improvement of VAS and KOOS-sports/recreation was significantly higher in patients with more severe cartilage lesions. Similarly, osteophyte lesions were associated significantly with improvement of VAS and KOOS-ADL, and BML was associated with KOOS-ADL and KOOS-sports/recreation. CONCLUSIONS: In intra-articular administration of autologous ASCs for knee OA, improvement of VAS and KOOS-sports/recreation was significantly higher in patients with more severe cartilage lesions. Similarly, osteophyte lesions were associated significantly with improvement of VAS and KOOS-ADL, and BML was associated with KOOS-ADL and KOOS-sports/recreation. Clinical studies with larger numbers of patients and various kinds of data are necessary to predict therapeutic effects. Japanese Society for Regenerative Medicine 2020-05-25 /pmc/articles/PMC7256437/ /pubmed/32490058 http://dx.doi.org/10.1016/j.reth.2020.04.003 Text en © 2020 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Higuchi, Junya
Yamagami, Ryota
Matsumoto, Takumi
Terao, Tomohiro
Inoue, Keita
Tsuji, Shinsaku
Maenohara, Yuji
Matsuzaki, Tokio
Chijimatsu, Ryota
Omata, Yasunori
Yano, Fumiko
Tanaka, Sakae
Saito, Taku
Associations of clinical outcomes and MRI findings in intra-articular administration of autologous adipose-derived stem cells for knee osteoarthritis
title Associations of clinical outcomes and MRI findings in intra-articular administration of autologous adipose-derived stem cells for knee osteoarthritis
title_full Associations of clinical outcomes and MRI findings in intra-articular administration of autologous adipose-derived stem cells for knee osteoarthritis
title_fullStr Associations of clinical outcomes and MRI findings in intra-articular administration of autologous adipose-derived stem cells for knee osteoarthritis
title_full_unstemmed Associations of clinical outcomes and MRI findings in intra-articular administration of autologous adipose-derived stem cells for knee osteoarthritis
title_short Associations of clinical outcomes and MRI findings in intra-articular administration of autologous adipose-derived stem cells for knee osteoarthritis
title_sort associations of clinical outcomes and mri findings in intra-articular administration of autologous adipose-derived stem cells for knee osteoarthritis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256437/
https://www.ncbi.nlm.nih.gov/pubmed/32490058
http://dx.doi.org/10.1016/j.reth.2020.04.003
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