Cargando…

Pulmonary Silicosis Alters MicroRNA Expression in Rat Lung and miR-411-3p Exerts Anti-fibrotic Effects by Inhibiting MRTF-A/SRF Signaling

To identify potential therapeutic targets for pulmonary fibrosis induced by silica, we studied the effects of this disease on the expression of microRNAs (miRNAs) in the lung. Rattus norvegicus pulmonary silicosis models were used in conjunction with high-throughput screening of lung specimens to co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Xuemin, Xu, Dingjie, Li, Shumin, Wei, Zhongqiu, Li, Shifeng, Cai, Wenchen, Mao, Na, Jin, Fuyu, Li, Yaqian, Yi, Xue, Liu, Heliang, Xu, Hong, Yang, Fang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256439/ https://www.ncbi.nlm.nih.gov/pubmed/32464548 http://dx.doi.org/10.1016/j.omtn.2020.05.005

Ejemplares similares

Inhibition of miR-155-5p Exerts Anti-Fibrotic Effects in Silicotic Mice by Regulating Meprin α
por: Chen, Yingying, et al.
Publicado: (2019)

MicroRNA‐411‐3p inhibits bleomycin‐induced skin fibrosis by regulating transforming growth factor‐β/Smad ubiquitin regulatory factor‐2 signalling
por: Zhang, Ziyan, et al.
Publicado: (2021)

Ac-SDKP Attenuates Activation of Lung Macrophages and Bone Osteoclasts in Rats Exposed to Silica by Inhibition of TLR4 and RANKL Signaling Pathways
por: Jin, Fuyu, et al.
Publicado: (2021)

Silica Perturbs Primary Cilia and Causes Myofibroblast Differentiation during Silicosis by Reduction of the KIF3A-Repressor GLI3 Complex
por: Li, Shifeng, et al.
Publicado: (2020)

Minute Cellular Nodules as Early Lesions in Rats with Silica Exposure via Inhalation
por: Li, Yaqian, et al.
Publicado: (2022)

Acetylated α-Tubulin Regulated by N-Acetyl-Seryl-Aspartyl-Lysyl-Proline(Ac-SDKP) Exerts the Anti-fibrotic Effect in Rat Lung Fibrosis Induced by Silica
por: Xiaojun, Wang, et al.
Publicado: (2016)

Glycolytic Reprogramming in Silica-Induced Lung Macrophages and Silicosis Reversed by Ac-SDKP Treatment
por: Mao, Na, et al.
Publicado: (2021)

MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells
por: Liu, Chen-Ying, et al.
Publicado: (2016)

Migration arrest of chemoresistant leukemia cells mediated by MRTF-SRF pathway
por: Morimatsu, Maho, et al.
Publicado: (2020)

Regulation of Dendritic Synaptic Morphology and Transcription by the SRF Cofactor MKL/MRTF
por: Tabuchi, Akiko, et al.
Publicado: (2021)

Circadian clock control of MRTF/SRF pathway suppresses beige adipocyte thermogenic recruitment
por: Xiong, Xuekai, et al.
Publicado: (2022)

Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis
por: Liu, Yan, et al.
Publicado: (2017)

Actomyosin and the MRTF-SRF pathway downregulate FGFR1 in mesenchymal stromal cells
por: Zonderland, Jip, et al.
Publicado: (2020)

Quercetin Alleviates Pulmonary Fibrosis in Mice Exposed to Silica by Inhibiting Macrophage Senescence
por: Geng, Fei, et al.
Publicado: (2022)

Prevention of bleomycin‐induced lung fibrosis via inhibition of the MRTF/SRF transcription pathway
por: Pawelec, Kendell M., et al.
Publicado: (2022)

Early Identification, Accurate Diagnosis, and Treatment of Silicosis
por: Li, Tian, et al.
Publicado: (2022)

HDAC6 Regulates the MRTF-A/SRF Axis and Vascular Smooth Muscle Cell Plasticity
por: Zhang, Mengxue, et al.
Publicado: (2018)

Exercise‐dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF‐SRF signalling
por: Solagna, Francesca, et al.
Publicado: (2020)

Oxamate Attenuates Glycolysis and ER Stress in Silicotic Mice
por: Mao, Na, et al.
Publicado: (2022)

Protein Expression Profile in Rat Silicosis Model Reveals Upregulation of PTPN2 and Its Inhibitory Effect on Epithelial-Mesenchymal Transition by Dephosphorylation of STAT3
por: Zhu, Ying, et al.
Publicado: (2020)

Cyclosporine A inhibits MRTF‐SRF signaling through Na(+)/K(+) ATPase inhibition and actin remodeling
por: Burat, Bastien, et al.
Publicado: (2019)

Single-molecule tracking (SMT) and localization of SRF and MRTF transcription factors during neuronal stimulation and differentiation
por: Kuchler, Oliver, et al.
Publicado: (2022)

Effect of Sex Differences in Silicotic Mice
por: Jin, Fuyu, et al.
Publicado: (2022)

Inhibition of MRTF activation as a clinically achievable anti-fibrotic mechanism for pirfenidone
por: Ma, Hsiao-Yen, et al.
Publicado: (2023)

Mutual dependence of the MRTF–SRF and YAP–TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics
por: Foster, Charles T., et al.
Publicado: (2017)

The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation via α-TAT1 gene expression
por: Fernández-Barrera, Jaime, et al.
Publicado: (2018)

In vitro and in vivo delivery of a sustained release nanocarrier-based formulation of an MRTF/SRF inhibitor in conjunctival fibrosis
por: Tagalakis, Aristides D., et al.
Publicado: (2018)

Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis
por: Yu-Wai-Man, Cynthia, et al.
Publicado: (2017)

Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion
por: Marco, Sergi, et al.
Publicado: (2021)

Quercetin Alleviates Pulmonary Fibrosis in Silicotic Mice by Inhibiting Macrophage Transition and TGF-β-Smad2/3 Pathway
por: Geng, Fei, et al.
Publicado: (2023)

Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts
por: Kepser, Lara-Jane, et al.
Publicado: (2021)

Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations
por: Le Dour, Caroline, et al.
Publicado: (2022)

Thalidomide Alleviates Pulmonary Fibrosis Induced by Silica in Mice by Inhibiting ER Stress and the TLR4-NF-κB Pathway
por: Li, Yaqian, et al.
Publicado: (2022)

A β2-Integrin/MRTF-A/SRF Pathway Regulates Dendritic Cell Gene Expression, Adhesion, and Traction Force Generation
por: Guenther, Carla, et al.
Publicado: (2019)

Paracrine HB-EGF signaling reduce enhanced contractile and energetic state of activated decidual fibroblasts by rebalancing SRF-MRTF-TCF transcriptional axis
por: Afzal, Junaid, et al.
Publicado: (2022)

The significance of serum S100 calcium-binding protein A4 in silicosis
por: Zhang, Jing, et al.
Publicado: (2022)

Transcriptomic analysis identifies upregulation of secreted phosphoprotein 1 in silicotic rats
por: Cai, Wenchen, et al.
Publicado: (2021)

A cAbl-MRTF-A Feedback Loop Contributes to Hepatic Stellate Cell Activation
por: Lu, Yunjie, et al.
Publicado: (2019)

Decreased Soluble Receptor of Advanced Glycation End Product Levels Correlated with Inflammation in Silicosis
por: Liu, Heliang, et al.
Publicado: (2020)

MRTF-A can activate Nrf2 to increase the resistance to doxorubicin
por: Xu, Yao, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_irh4rldeaclvvo54lefdq7a9i5