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SARS-CoV-2 antibody testing—questions to be asked

Severe acute respiratory syndrome coronavirus 2 infection and development of coronavirus disease 2019 presents a major health care challenge of global dimensions. Laboratory diagnostics of infected patients, and the assessment of immunity against severe acute respiratory syndrome coronavirus 2, pres...

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Autores principales: Özçürümez, Mustafa K., Ambrosch, Andreas, Frey, Oliver, Haselmann, Verena, Holdenrieder, Stefan, Kiehntopf, Michael, Neumaier, Michael, Walter, Michael, Wenzel, Folker, Wölfel, Roman, Renz, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Academy of Allergy, Asthma & Immunology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256507/
https://www.ncbi.nlm.nih.gov/pubmed/32479758
http://dx.doi.org/10.1016/j.jaci.2020.05.020
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author Özçürümez, Mustafa K.
Ambrosch, Andreas
Frey, Oliver
Haselmann, Verena
Holdenrieder, Stefan
Kiehntopf, Michael
Neumaier, Michael
Walter, Michael
Wenzel, Folker
Wölfel, Roman
Renz, Harald
author_facet Özçürümez, Mustafa K.
Ambrosch, Andreas
Frey, Oliver
Haselmann, Verena
Holdenrieder, Stefan
Kiehntopf, Michael
Neumaier, Michael
Walter, Michael
Wenzel, Folker
Wölfel, Roman
Renz, Harald
author_sort Özçürümez, Mustafa K.
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 infection and development of coronavirus disease 2019 presents a major health care challenge of global dimensions. Laboratory diagnostics of infected patients, and the assessment of immunity against severe acute respiratory syndrome coronavirus 2, presents a major cornerstone in handling the pandemic. Currently, there is an increase in demand for antibody testing and a large number of tests are already marketed or are in the late stage of development. However, the interpretation of test results depends on many variables and factors, including sensitivity, specificity, potential cross-reactivity and cross-protectivity, the diagnostic value of antibodies of different isotypes, and the use of antibody testing in identification of acutely ill patients or in epidemiological settings. In this article, the recently established COVID-19 Task Force of the German Society for Clinical Chemistry and Laboratory Medicine (DGKL) addresses these issues on the basis of currently available data sets in this rapidly moving field.
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spelling pubmed-72565072020-05-29 SARS-CoV-2 antibody testing—questions to be asked Özçürümez, Mustafa K. Ambrosch, Andreas Frey, Oliver Haselmann, Verena Holdenrieder, Stefan Kiehntopf, Michael Neumaier, Michael Walter, Michael Wenzel, Folker Wölfel, Roman Renz, Harald J Allergy Clin Immunol Reviews and Feature Articles Severe acute respiratory syndrome coronavirus 2 infection and development of coronavirus disease 2019 presents a major health care challenge of global dimensions. Laboratory diagnostics of infected patients, and the assessment of immunity against severe acute respiratory syndrome coronavirus 2, presents a major cornerstone in handling the pandemic. Currently, there is an increase in demand for antibody testing and a large number of tests are already marketed or are in the late stage of development. However, the interpretation of test results depends on many variables and factors, including sensitivity, specificity, potential cross-reactivity and cross-protectivity, the diagnostic value of antibodies of different isotypes, and the use of antibody testing in identification of acutely ill patients or in epidemiological settings. In this article, the recently established COVID-19 Task Force of the German Society for Clinical Chemistry and Laboratory Medicine (DGKL) addresses these issues on the basis of currently available data sets in this rapidly moving field. American Academy of Allergy, Asthma & Immunology 2020-07 2020-05-29 /pmc/articles/PMC7256507/ /pubmed/32479758 http://dx.doi.org/10.1016/j.jaci.2020.05.020 Text en © 2020 American Academy of Allergy, Asthma & Immunology. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Reviews and Feature Articles
Özçürümez, Mustafa K.
Ambrosch, Andreas
Frey, Oliver
Haselmann, Verena
Holdenrieder, Stefan
Kiehntopf, Michael
Neumaier, Michael
Walter, Michael
Wenzel, Folker
Wölfel, Roman
Renz, Harald
SARS-CoV-2 antibody testing—questions to be asked
title SARS-CoV-2 antibody testing—questions to be asked
title_full SARS-CoV-2 antibody testing—questions to be asked
title_fullStr SARS-CoV-2 antibody testing—questions to be asked
title_full_unstemmed SARS-CoV-2 antibody testing—questions to be asked
title_short SARS-CoV-2 antibody testing—questions to be asked
title_sort sars-cov-2 antibody testing—questions to be asked
topic Reviews and Feature Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256507/
https://www.ncbi.nlm.nih.gov/pubmed/32479758
http://dx.doi.org/10.1016/j.jaci.2020.05.020
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