Clinically significant anticardiolipin antibodies associated with COVID-19

The novel coronavirus strain known as SARS-CoV-2 has rapidly spread around the world creating distinct challenges to the healthcare workforce. Coagulopathy contributing to significant morbidity in critically ill patients with SARS-CoV-2 has now been well documented. We discuss two cases selected fro...

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Autores principales: Hossri, Sami, Shadi, Mahmoud, Hamarsha, Zaid, Schneider, Rick, El-Sayegh, Dany
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256550/
https://www.ncbi.nlm.nih.gov/pubmed/32512349
http://dx.doi.org/10.1016/j.jcrc.2020.05.017
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author Hossri, Sami
Shadi, Mahmoud
Hamarsha, Zaid
Schneider, Rick
El-Sayegh, Dany
author_facet Hossri, Sami
Shadi, Mahmoud
Hamarsha, Zaid
Schneider, Rick
El-Sayegh, Dany
author_sort Hossri, Sami
collection PubMed
description The novel coronavirus strain known as SARS-CoV-2 has rapidly spread around the world creating distinct challenges to the healthcare workforce. Coagulopathy contributing to significant morbidity in critically ill patients with SARS-CoV-2 has now been well documented. We discuss two cases selected from patients requiring critical care in April 2020 in New York City with a unique clinical course. Both cases reveal significant thrombotic events noted on imaging during their hospital course. Obtaining serial inflammatory markers in conjunction with anti-phospholipid antibody testing revealed clinically significant Antiphospholipid syndrome (APS). This case series reviews the details preceding APS observed in SARS-CoV-2 and aims to report findings that could potentially further our understanding of the disease.
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spelling pubmed-72565502020-05-29 Clinically significant anticardiolipin antibodies associated with COVID-19 Hossri, Sami Shadi, Mahmoud Hamarsha, Zaid Schneider, Rick El-Sayegh, Dany J Crit Care Article The novel coronavirus strain known as SARS-CoV-2 has rapidly spread around the world creating distinct challenges to the healthcare workforce. Coagulopathy contributing to significant morbidity in critically ill patients with SARS-CoV-2 has now been well documented. We discuss two cases selected from patients requiring critical care in April 2020 in New York City with a unique clinical course. Both cases reveal significant thrombotic events noted on imaging during their hospital course. Obtaining serial inflammatory markers in conjunction with anti-phospholipid antibody testing revealed clinically significant Antiphospholipid syndrome (APS). This case series reviews the details preceding APS observed in SARS-CoV-2 and aims to report findings that could potentially further our understanding of the disease. Elsevier Inc. 2020-10 2020-05-29 /pmc/articles/PMC7256550/ /pubmed/32512349 http://dx.doi.org/10.1016/j.jcrc.2020.05.017 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Hossri, Sami
Shadi, Mahmoud
Hamarsha, Zaid
Schneider, Rick
El-Sayegh, Dany
Clinically significant anticardiolipin antibodies associated with COVID-19
title Clinically significant anticardiolipin antibodies associated with COVID-19
title_full Clinically significant anticardiolipin antibodies associated with COVID-19
title_fullStr Clinically significant anticardiolipin antibodies associated with COVID-19
title_full_unstemmed Clinically significant anticardiolipin antibodies associated with COVID-19
title_short Clinically significant anticardiolipin antibodies associated with COVID-19
title_sort clinically significant anticardiolipin antibodies associated with covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256550/
https://www.ncbi.nlm.nih.gov/pubmed/32512349
http://dx.doi.org/10.1016/j.jcrc.2020.05.017
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