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The effect of LTA gene polymorphisms on cancer risk: an updated systematic review and meta- analysis
Purpose: To provide a comprehensive account of the association of five Lymphotoxin-α (LTA) gene polymorphisms (rs1041981, rs2229094, rs2239704, rs746868, rs909253) with susceptibility to cancer. Methods: A literature search for eligible candidate gene studies published before 28 February 2020 was co...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256675/ https://www.ncbi.nlm.nih.gov/pubmed/32420584 http://dx.doi.org/10.1042/BSR20192320 |
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author | Li, Jingdong Wang, Yaxuan Chang, Xueliang Han, Zhenwei |
author_facet | Li, Jingdong Wang, Yaxuan Chang, Xueliang Han, Zhenwei |
author_sort | Li, Jingdong |
collection | PubMed |
description | Purpose: To provide a comprehensive account of the association of five Lymphotoxin-α (LTA) gene polymorphisms (rs1041981, rs2229094, rs2239704, rs746868, rs909253) with susceptibility to cancer. Methods: A literature search for eligible candidate gene studies published before 28 February 2020 was conducted in the PubMed, Medline, Google Scholar and Web of Science. The following combinations of main keywords were used: (LTA OR Lymphotoxin alpha OR TNF-β OR tumor necrosis factor-beta) AND (polymorphism OR mutation OR variation OR SNP OR genotype) AND (cancer OR tumor OR neoplasm OR malignancy OR carcinoma OR adenocarcinoma). Potential sources of heterogeneity were sought out via subgroup and sensitivity analysis, and publication bias were estimated. Results: Overall, a total of 24 articles with 24577 cases and 33351 controls for five polymorphisms of LTA gene were enrolled. We identified that rs2239704 was associated with a reduced risk of cancer. While for other polymorphisms, the results showed no significant association with cancer risk. In the stratified analysis of rs1041981, we found that Asians might have less susceptibility to cancer. At the same time, we found that rs2239704 was negatively correlated with non-Hodgkin lymphoma (NHL). While, for rs909253, an increased risk of cancer for Caucasians and HCC susceptibility were uncovered in the stratified analysis of by ethnicity and cancer type. Conclusion: LTA rs2239704 polymorphism is inversely associated with the risk of cancer. LTA rs1041981 polymorphism is negatively associated with cancer risk in Asia. While, LTA rs909253 polymorphism is a risk factor for HCC in Caucasian population. |
format | Online Article Text |
id | pubmed-7256675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72566752020-06-08 The effect of LTA gene polymorphisms on cancer risk: an updated systematic review and meta- analysis Li, Jingdong Wang, Yaxuan Chang, Xueliang Han, Zhenwei Biosci Rep Cancer Purpose: To provide a comprehensive account of the association of five Lymphotoxin-α (LTA) gene polymorphisms (rs1041981, rs2229094, rs2239704, rs746868, rs909253) with susceptibility to cancer. Methods: A literature search for eligible candidate gene studies published before 28 February 2020 was conducted in the PubMed, Medline, Google Scholar and Web of Science. The following combinations of main keywords were used: (LTA OR Lymphotoxin alpha OR TNF-β OR tumor necrosis factor-beta) AND (polymorphism OR mutation OR variation OR SNP OR genotype) AND (cancer OR tumor OR neoplasm OR malignancy OR carcinoma OR adenocarcinoma). Potential sources of heterogeneity were sought out via subgroup and sensitivity analysis, and publication bias were estimated. Results: Overall, a total of 24 articles with 24577 cases and 33351 controls for five polymorphisms of LTA gene were enrolled. We identified that rs2239704 was associated with a reduced risk of cancer. While for other polymorphisms, the results showed no significant association with cancer risk. In the stratified analysis of rs1041981, we found that Asians might have less susceptibility to cancer. At the same time, we found that rs2239704 was negatively correlated with non-Hodgkin lymphoma (NHL). While, for rs909253, an increased risk of cancer for Caucasians and HCC susceptibility were uncovered in the stratified analysis of by ethnicity and cancer type. Conclusion: LTA rs2239704 polymorphism is inversely associated with the risk of cancer. LTA rs1041981 polymorphism is negatively associated with cancer risk in Asia. While, LTA rs909253 polymorphism is a risk factor for HCC in Caucasian population. Portland Press Ltd. 2020-05-28 /pmc/articles/PMC7256675/ /pubmed/32420584 http://dx.doi.org/10.1042/BSR20192320 Text en © 2020 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY). |
spellingShingle | Cancer Li, Jingdong Wang, Yaxuan Chang, Xueliang Han, Zhenwei The effect of LTA gene polymorphisms on cancer risk: an updated systematic review and meta- analysis |
title | The effect of LTA gene polymorphisms on cancer risk: an updated systematic review and meta- analysis |
title_full | The effect of LTA gene polymorphisms on cancer risk: an updated systematic review and meta- analysis |
title_fullStr | The effect of LTA gene polymorphisms on cancer risk: an updated systematic review and meta- analysis |
title_full_unstemmed | The effect of LTA gene polymorphisms on cancer risk: an updated systematic review and meta- analysis |
title_short | The effect of LTA gene polymorphisms on cancer risk: an updated systematic review and meta- analysis |
title_sort | effect of lta gene polymorphisms on cancer risk: an updated systematic review and meta- analysis |
topic | Cancer |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256675/ https://www.ncbi.nlm.nih.gov/pubmed/32420584 http://dx.doi.org/10.1042/BSR20192320 |
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