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The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids

BACKGROUND: Psoriasis is a chronic systemic inflammatory disease associated with a wide range of comorbidities, including metabolic syndrome (MetS). Serum calprotectin, ANGPTL8, and oxidative damage to nucleic acids might be associated with both diseases. The presented study describes the influence...

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Autores principales: Holmannova, Drahomira, Borska, Lenka, Andrys, Ctirad, Borsky, Pavel, Kremlacek, Jan, Hamakova, Kvetoslava, Rehacek, Vit, Malkova, Andrea, Svadlakova, Tereza, Palicka, Vladimir, Krejsek, Jan, Fiala, Zdenek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256681/
https://www.ncbi.nlm.nih.gov/pubmed/32537470
http://dx.doi.org/10.1155/2020/7352637
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author Holmannova, Drahomira
Borska, Lenka
Andrys, Ctirad
Borsky, Pavel
Kremlacek, Jan
Hamakova, Kvetoslava
Rehacek, Vit
Malkova, Andrea
Svadlakova, Tereza
Palicka, Vladimir
Krejsek, Jan
Fiala, Zdenek
author_facet Holmannova, Drahomira
Borska, Lenka
Andrys, Ctirad
Borsky, Pavel
Kremlacek, Jan
Hamakova, Kvetoslava
Rehacek, Vit
Malkova, Andrea
Svadlakova, Tereza
Palicka, Vladimir
Krejsek, Jan
Fiala, Zdenek
author_sort Holmannova, Drahomira
collection PubMed
description BACKGROUND: Psoriasis is a chronic systemic inflammatory disease associated with a wide range of comorbidities, including metabolic syndrome (MetS). Serum calprotectin, ANGPTL8, and oxidative damage to nucleic acids might be associated with both diseases. The presented study describes the influence of psoriasis and MetS on the serum levels of markers of systemic inflammation (calprotectin and ANGPTL8) and markers of oxidative damage to nucleic acids. The applicability of serum levels of calprotectin and ANGPTL8 for monitoring of the activity of psoriasis (diagnostic markers) is also evaluated. METHODS: Clinical examination (PASI score, MetS), enzyme-linked immunosorbent assay (ELISA), and Enzyme Immunoassay (EIA). Serum calprotectin, ANGPTL8, 8-hydroxy-2′-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine. Results and Conclusions. The psoriasis significantly increased the serum level of calprotectin and the serum level of oxidative damage to nucleic acids, however not the serum level of ANGPTL8. The presence of MetS did not significantly affect the serum levels of calprotectin, ANGPTL8, and oxidative damage to nucleic acids in either psoriasis patients or controls. It seems that the serum level of calprotectin (but not the serum level of ANGPTL8) could be used as a biomarker for monitoring the activity of psoriasis.
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spelling pubmed-72566812020-06-13 The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids Holmannova, Drahomira Borska, Lenka Andrys, Ctirad Borsky, Pavel Kremlacek, Jan Hamakova, Kvetoslava Rehacek, Vit Malkova, Andrea Svadlakova, Tereza Palicka, Vladimir Krejsek, Jan Fiala, Zdenek J Immunol Res Research Article BACKGROUND: Psoriasis is a chronic systemic inflammatory disease associated with a wide range of comorbidities, including metabolic syndrome (MetS). Serum calprotectin, ANGPTL8, and oxidative damage to nucleic acids might be associated with both diseases. The presented study describes the influence of psoriasis and MetS on the serum levels of markers of systemic inflammation (calprotectin and ANGPTL8) and markers of oxidative damage to nucleic acids. The applicability of serum levels of calprotectin and ANGPTL8 for monitoring of the activity of psoriasis (diagnostic markers) is also evaluated. METHODS: Clinical examination (PASI score, MetS), enzyme-linked immunosorbent assay (ELISA), and Enzyme Immunoassay (EIA). Serum calprotectin, ANGPTL8, 8-hydroxy-2′-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine. Results and Conclusions. The psoriasis significantly increased the serum level of calprotectin and the serum level of oxidative damage to nucleic acids, however not the serum level of ANGPTL8. The presence of MetS did not significantly affect the serum levels of calprotectin, ANGPTL8, and oxidative damage to nucleic acids in either psoriasis patients or controls. It seems that the serum level of calprotectin (but not the serum level of ANGPTL8) could be used as a biomarker for monitoring the activity of psoriasis. Hindawi 2020-05-20 /pmc/articles/PMC7256681/ /pubmed/32537470 http://dx.doi.org/10.1155/2020/7352637 Text en Copyright © 2020 Drahomira Holmannova et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Holmannova, Drahomira
Borska, Lenka
Andrys, Ctirad
Borsky, Pavel
Kremlacek, Jan
Hamakova, Kvetoslava
Rehacek, Vit
Malkova, Andrea
Svadlakova, Tereza
Palicka, Vladimir
Krejsek, Jan
Fiala, Zdenek
The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids
title The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids
title_full The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids
title_fullStr The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids
title_full_unstemmed The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids
title_short The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids
title_sort impact of psoriasis and metabolic syndrome on the systemic inflammation and oxidative damage to nucleic acids
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256681/
https://www.ncbi.nlm.nih.gov/pubmed/32537470
http://dx.doi.org/10.1155/2020/7352637
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