Global Transcriptome Changes of Biofilm-Forming Staphylococcus epidermidis Responding to Total Alkaloids of Sophorea alopecuroides

Transcriptome changes of biofilm-forming Staphylococcus epidermidis response to total alkaloids of Sophorea alopecuroides was observed. Bioinformatic analyses were further used to compare the differential gene expression between control and the treated samples. It was found that 282 genes were diffe...

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Autores principales: GUAN, CUI-PING, LUO, HUI-XIA, FANG, H.E., ZHOU, XUE-ZHANG
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Exeley Inc. 2018
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256688/
https://www.ncbi.nlm.nih.gov/pubmed/30015461
http://dx.doi.org/10.21307/pjm-2018-024
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author GUAN, CUI-PING
LUO, HUI-XIA
FANG, H.E.
ZHOU, XUE-ZHANG
author_facet GUAN, CUI-PING
LUO, HUI-XIA
FANG, H.E.
ZHOU, XUE-ZHANG
author_sort GUAN, CUI-PING
collection PubMed
description Transcriptome changes of biofilm-forming Staphylococcus epidermidis response to total alkaloids of Sophorea alopecuroides was observed. Bioinformatic analyses were further used to compare the differential gene expression between control and the treated samples. It was found that 282 genes were differentially expressed, with 92 up-regulated and 190 down-regulated. These involved down-regulation of the sulfur metabolism pathway. It was suggested that inhibitory effects on Staphylococcus epidermidis and its biofilm formation of the total alkaloids of S. alopecuroides was mainly due to the regulation of the sulfur metabolism pathways of S. epidermidis.
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spelling pubmed-72566882020-06-03 Global Transcriptome Changes of Biofilm-Forming Staphylococcus epidermidis Responding to Total Alkaloids of Sophorea alopecuroides GUAN, CUI-PING LUO, HUI-XIA FANG, H.E. ZHOU, XUE-ZHANG Pol J Microbiol Microbiology Transcriptome changes of biofilm-forming Staphylococcus epidermidis response to total alkaloids of Sophorea alopecuroides was observed. Bioinformatic analyses were further used to compare the differential gene expression between control and the treated samples. It was found that 282 genes were differentially expressed, with 92 up-regulated and 190 down-regulated. These involved down-regulation of the sulfur metabolism pathway. It was suggested that inhibitory effects on Staphylococcus epidermidis and its biofilm formation of the total alkaloids of S. alopecuroides was mainly due to the regulation of the sulfur metabolism pathways of S. epidermidis. Exeley Inc. 2018-06 2018-06-30 /pmc/articles/PMC7256688/ /pubmed/30015461 http://dx.doi.org/10.21307/pjm-2018-024 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Microbiology
GUAN, CUI-PING
LUO, HUI-XIA
FANG, H.E.
ZHOU, XUE-ZHANG
Global Transcriptome Changes of Biofilm-Forming Staphylococcus epidermidis Responding to Total Alkaloids of Sophorea alopecuroides
title Global Transcriptome Changes of Biofilm-Forming Staphylococcus epidermidis Responding to Total Alkaloids of Sophorea alopecuroides
title_full Global Transcriptome Changes of Biofilm-Forming Staphylococcus epidermidis Responding to Total Alkaloids of Sophorea alopecuroides
title_fullStr Global Transcriptome Changes of Biofilm-Forming Staphylococcus epidermidis Responding to Total Alkaloids of Sophorea alopecuroides
title_full_unstemmed Global Transcriptome Changes of Biofilm-Forming Staphylococcus epidermidis Responding to Total Alkaloids of Sophorea alopecuroides
title_short Global Transcriptome Changes of Biofilm-Forming Staphylococcus epidermidis Responding to Total Alkaloids of Sophorea alopecuroides
title_sort global transcriptome changes of biofilm-forming staphylococcus epidermidis responding to total alkaloids of sophorea alopecuroides
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256688/
https://www.ncbi.nlm.nih.gov/pubmed/30015461
http://dx.doi.org/10.21307/pjm-2018-024
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