Cargando…
An Epoxide Intermediate in Glycosidase Catalysis
[Image: see text] Retaining glycoside hydrolases cleave their substrates through stereochemical retention at the anomeric position. Typically, this involves two-step mechanisms using either an enzymatic nucleophile via a covalent glycosyl enzyme intermediate or neighboring-group participation by a s...
Autores principales: | Sobala, Lukasz F., Speciale, Gaetano, Zhu, Sha, Raich, Lluís, Sannikova, Natalia, Thompson, Andrew J., Hakki, Zalihe, Lu, Dan, Shamsi Kazem Abadi, Saeideh, Lewis, Andrew R., Rojas-Cervellera, Víctor, Bernardo-Seisdedos, Ganeko, Zhang, Yongmin, Millet, Oscar, Jiménez-Barbero, Jesús, Bennet, Andrew J., Sollogoub, Matthieu, Rovira, Carme, Davies, Gideon J., Williams, Spencer J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2020
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256955/ https://www.ncbi.nlm.nih.gov/pubmed/32490192 http://dx.doi.org/10.1021/acscentsci.0c00111 |
Ejemplares similares
-
Contribution
of Shape and Charge to the Inhibition
of a Family GH99 endo-α-1,2-Mannanase
por: Petricevic, Marija, et al.
Publicado: (2016) -
Dissecting conformational contributions to glycosidase catalysis and inhibition
por: Speciale, Gaetano, et al.
Publicado: (2014) -
1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible
Glycosidase Inhibitor
por: Artola, Marta, et al.
Publicado: (2017) -
Structural Snapshots for Mechanism‐Based Inactivation of a Glycoside Hydrolase by Cyclopropyl Carbasugars
por: Adamson, Christopher, et al.
Publicado: (2016) -
In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity‐based protein profiling
por: Kuo, Chi‐Lin, et al.
Publicado: (2019)