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Maternal cardiovascular adaptation to twin pregnancy: a population-based prospective cohort study
BACKGROUND: In women with singleton pregnancies, maternal adaptation is considered a stress test for later life cardiovascular disease. The aim of this study was to assess maternal adaptation in women with twin pregnancies compared to women carrying singletons during and after pregnancy. METHODS: Th...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257120/ https://www.ncbi.nlm.nih.gov/pubmed/32471487 http://dx.doi.org/10.1186/s12884-020-02994-w |
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author | Adank, Maria C. Broere-Brown, Zoe A. Gonçalves, Romy Ikram, M. Kamran Jaddoe, Vincent W. V. Steegers, Eric A. P. Schalekamp-Timmermans, Sarah |
author_facet | Adank, Maria C. Broere-Brown, Zoe A. Gonçalves, Romy Ikram, M. Kamran Jaddoe, Vincent W. V. Steegers, Eric A. P. Schalekamp-Timmermans, Sarah |
author_sort | Adank, Maria C. |
collection | PubMed |
description | BACKGROUND: In women with singleton pregnancies, maternal adaptation is considered a stress test for later life cardiovascular disease. The aim of this study was to assess maternal adaptation in women with twin pregnancies compared to women carrying singletons during and after pregnancy. METHODS: This was a population based prospective cohort study of 91 women with twin pregnancies and 8107 women carrying singletons. The association of twin pregnancy and maternal adaptation was examined using regression analyses. In pregnancy, we measured soluble fms-like tyrosine kinase-1 (sFLT-1), placental growth (PGF) factor, systolic (SBP) and diastolic blood pressure (DBP), and the occurrence of pre-eclampsia (PE). After pregnancy, measurements were obtained on SBP and DBP, cardiac function, retinal calibres, intima media thickness and distensibility of the common carotid artery. RESULTS: sFLT-1 and PGF concentrations were higher in early (13.4 weeks) and mid-pregnancy (20.4 weeks) in women with twin pregnancies compared to women with singleton pregnancies. Women with twin pregnancies had a different DBP pattern in pregnancy. Women with twin pregnancies were more likely to have PE (odds ratio 3.63; 95% CI [1.76 to 7.48]). Six and ten years after pregnancy, no differences in maternal adaptation were observed. CONCLUSIONS: Women with twin pregnancies show an altered adaptation during pregnancy compared to women with singleton pregnancies. This is associated with a substantially increased incidence of PE, but does not lead to persistent altered maternal adaptation years after pregnancy. |
format | Online Article Text |
id | pubmed-7257120 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-72571202020-06-07 Maternal cardiovascular adaptation to twin pregnancy: a population-based prospective cohort study Adank, Maria C. Broere-Brown, Zoe A. Gonçalves, Romy Ikram, M. Kamran Jaddoe, Vincent W. V. Steegers, Eric A. P. Schalekamp-Timmermans, Sarah BMC Pregnancy Childbirth Research Article BACKGROUND: In women with singleton pregnancies, maternal adaptation is considered a stress test for later life cardiovascular disease. The aim of this study was to assess maternal adaptation in women with twin pregnancies compared to women carrying singletons during and after pregnancy. METHODS: This was a population based prospective cohort study of 91 women with twin pregnancies and 8107 women carrying singletons. The association of twin pregnancy and maternal adaptation was examined using regression analyses. In pregnancy, we measured soluble fms-like tyrosine kinase-1 (sFLT-1), placental growth (PGF) factor, systolic (SBP) and diastolic blood pressure (DBP), and the occurrence of pre-eclampsia (PE). After pregnancy, measurements were obtained on SBP and DBP, cardiac function, retinal calibres, intima media thickness and distensibility of the common carotid artery. RESULTS: sFLT-1 and PGF concentrations were higher in early (13.4 weeks) and mid-pregnancy (20.4 weeks) in women with twin pregnancies compared to women with singleton pregnancies. Women with twin pregnancies had a different DBP pattern in pregnancy. Women with twin pregnancies were more likely to have PE (odds ratio 3.63; 95% CI [1.76 to 7.48]). Six and ten years after pregnancy, no differences in maternal adaptation were observed. CONCLUSIONS: Women with twin pregnancies show an altered adaptation during pregnancy compared to women with singleton pregnancies. This is associated with a substantially increased incidence of PE, but does not lead to persistent altered maternal adaptation years after pregnancy. BioMed Central 2020-05-29 /pmc/articles/PMC7257120/ /pubmed/32471487 http://dx.doi.org/10.1186/s12884-020-02994-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Adank, Maria C. Broere-Brown, Zoe A. Gonçalves, Romy Ikram, M. Kamran Jaddoe, Vincent W. V. Steegers, Eric A. P. Schalekamp-Timmermans, Sarah Maternal cardiovascular adaptation to twin pregnancy: a population-based prospective cohort study |
title | Maternal cardiovascular adaptation to twin pregnancy: a population-based prospective cohort study |
title_full | Maternal cardiovascular adaptation to twin pregnancy: a population-based prospective cohort study |
title_fullStr | Maternal cardiovascular adaptation to twin pregnancy: a population-based prospective cohort study |
title_full_unstemmed | Maternal cardiovascular adaptation to twin pregnancy: a population-based prospective cohort study |
title_short | Maternal cardiovascular adaptation to twin pregnancy: a population-based prospective cohort study |
title_sort | maternal cardiovascular adaptation to twin pregnancy: a population-based prospective cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257120/ https://www.ncbi.nlm.nih.gov/pubmed/32471487 http://dx.doi.org/10.1186/s12884-020-02994-w |
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