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The impact of remission and coexisting migraine on anxiety and depression in cluster headache

BACKGROUND: Our aim was to investigate the relationship between coexisting cluster headache (CH) and migraine with anxiety and depression during active cluster bouts, and how symptoms change during remission. METHODS: We analyzed data from 222 consecutive CH patients and 99 age- and sex-matched cont...

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Autores principales: Kim, Byung-Su, Chung, Pil-Wook, Kim, Byung-Kun, Lee, Mi Ji, Park, Jeong Wook, Chu, Min Kyung, Ahn, Jin-Young, Bae, Dae Woong, Song, Tae-Jin, Sohn, Jong-Hee, Oh, Kyungmi, Kim, Daeyoung, Kim, Jae-Moon, Kim, Soo-Kyoung, Choi, Yun-Ju, Chung, Jae Myun, Moon, Heui-Soo, Chung, Chin-Sang, Park, Kwang-Yeol, Cho, Soo-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257141/
https://www.ncbi.nlm.nih.gov/pubmed/32471362
http://dx.doi.org/10.1186/s10194-020-01120-7
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author Kim, Byung-Su
Chung, Pil-Wook
Kim, Byung-Kun
Lee, Mi Ji
Park, Jeong Wook
Chu, Min Kyung
Ahn, Jin-Young
Bae, Dae Woong
Song, Tae-Jin
Sohn, Jong-Hee
Oh, Kyungmi
Kim, Daeyoung
Kim, Jae-Moon
Kim, Soo-Kyoung
Choi, Yun-Ju
Chung, Jae Myun
Moon, Heui-Soo
Chung, Chin-Sang
Park, Kwang-Yeol
Cho, Soo-Jin
author_facet Kim, Byung-Su
Chung, Pil-Wook
Kim, Byung-Kun
Lee, Mi Ji
Park, Jeong Wook
Chu, Min Kyung
Ahn, Jin-Young
Bae, Dae Woong
Song, Tae-Jin
Sohn, Jong-Hee
Oh, Kyungmi
Kim, Daeyoung
Kim, Jae-Moon
Kim, Soo-Kyoung
Choi, Yun-Ju
Chung, Jae Myun
Moon, Heui-Soo
Chung, Chin-Sang
Park, Kwang-Yeol
Cho, Soo-Jin
author_sort Kim, Byung-Su
collection PubMed
description BACKGROUND: Our aim was to investigate the relationship between coexisting cluster headache (CH) and migraine with anxiety and depression during active cluster bouts, and how symptoms change during remission. METHODS: We analyzed data from 222 consecutive CH patients and 99 age- and sex-matched controls using a prospective multicenter registry. Anxiety or depression was evaluated using the Generalized Anxiety Disorder-7 (GAD-7) or Patient Health Questionnaire-9 (PHQ-9), respectively. Moderate-to-severe anxiety or depression was defined as a score of ≥10 at baseline (during a cluster bout). We assessed for changes in anxiety and depression during CH remission periods. RESULTS: Among the CH patients, the prevalence of moderate-to-severe anxiety and depression was seen in 38.2% and 34.6%, respectively. Compared with controls, CH patients were associated with moderate-to-severe anxiety and depression (multivariable-adjusted odds ratio [aOR] = 7.32, 95% confidence intervals [CI] = 3.35–15.99 and aOR = 4.95, 95% CI = 2.32–10.57, respectively). CH patients with migraine were significantly more likely to have moderate-to-severe anxiety and depression (aOR = 32.53, 95% CI = 6.63–159.64 and aOR = 16.88, 95% CI = 4.16–68.38, respectively), compared to controls without migraine. The GAD-7 and PHQ-9 scores were significantly reduced between cluster bout and remission periods (from 6.8 ± 5.6 to 1.6 ± 2.8; P < 0.001, and from 6.1 ± 5.0 to 1.8 ± 2.4; P < 0.001, respectively). CONCLUSIONS: Our results indicate that CH patients are at increased risk of anxiety and depression, especially in the presence of coexisting migraine. However, the anxiety and depression can improve during remission periods.
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spelling pubmed-72571412020-06-07 The impact of remission and coexisting migraine on anxiety and depression in cluster headache Kim, Byung-Su Chung, Pil-Wook Kim, Byung-Kun Lee, Mi Ji Park, Jeong Wook Chu, Min Kyung Ahn, Jin-Young Bae, Dae Woong Song, Tae-Jin Sohn, Jong-Hee Oh, Kyungmi Kim, Daeyoung Kim, Jae-Moon Kim, Soo-Kyoung Choi, Yun-Ju Chung, Jae Myun Moon, Heui-Soo Chung, Chin-Sang Park, Kwang-Yeol Cho, Soo-Jin J Headache Pain Research Article BACKGROUND: Our aim was to investigate the relationship between coexisting cluster headache (CH) and migraine with anxiety and depression during active cluster bouts, and how symptoms change during remission. METHODS: We analyzed data from 222 consecutive CH patients and 99 age- and sex-matched controls using a prospective multicenter registry. Anxiety or depression was evaluated using the Generalized Anxiety Disorder-7 (GAD-7) or Patient Health Questionnaire-9 (PHQ-9), respectively. Moderate-to-severe anxiety or depression was defined as a score of ≥10 at baseline (during a cluster bout). We assessed for changes in anxiety and depression during CH remission periods. RESULTS: Among the CH patients, the prevalence of moderate-to-severe anxiety and depression was seen in 38.2% and 34.6%, respectively. Compared with controls, CH patients were associated with moderate-to-severe anxiety and depression (multivariable-adjusted odds ratio [aOR] = 7.32, 95% confidence intervals [CI] = 3.35–15.99 and aOR = 4.95, 95% CI = 2.32–10.57, respectively). CH patients with migraine were significantly more likely to have moderate-to-severe anxiety and depression (aOR = 32.53, 95% CI = 6.63–159.64 and aOR = 16.88, 95% CI = 4.16–68.38, respectively), compared to controls without migraine. The GAD-7 and PHQ-9 scores were significantly reduced between cluster bout and remission periods (from 6.8 ± 5.6 to 1.6 ± 2.8; P < 0.001, and from 6.1 ± 5.0 to 1.8 ± 2.4; P < 0.001, respectively). CONCLUSIONS: Our results indicate that CH patients are at increased risk of anxiety and depression, especially in the presence of coexisting migraine. However, the anxiety and depression can improve during remission periods. Springer Milan 2020-05-29 /pmc/articles/PMC7257141/ /pubmed/32471362 http://dx.doi.org/10.1186/s10194-020-01120-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Kim, Byung-Su
Chung, Pil-Wook
Kim, Byung-Kun
Lee, Mi Ji
Park, Jeong Wook
Chu, Min Kyung
Ahn, Jin-Young
Bae, Dae Woong
Song, Tae-Jin
Sohn, Jong-Hee
Oh, Kyungmi
Kim, Daeyoung
Kim, Jae-Moon
Kim, Soo-Kyoung
Choi, Yun-Ju
Chung, Jae Myun
Moon, Heui-Soo
Chung, Chin-Sang
Park, Kwang-Yeol
Cho, Soo-Jin
The impact of remission and coexisting migraine on anxiety and depression in cluster headache
title The impact of remission and coexisting migraine on anxiety and depression in cluster headache
title_full The impact of remission and coexisting migraine on anxiety and depression in cluster headache
title_fullStr The impact of remission and coexisting migraine on anxiety and depression in cluster headache
title_full_unstemmed The impact of remission and coexisting migraine on anxiety and depression in cluster headache
title_short The impact of remission and coexisting migraine on anxiety and depression in cluster headache
title_sort impact of remission and coexisting migraine on anxiety and depression in cluster headache
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257141/
https://www.ncbi.nlm.nih.gov/pubmed/32471362
http://dx.doi.org/10.1186/s10194-020-01120-7
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