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Restoration of KMT2C/MLL3 in human colorectal cancer cells reinforces genome-wide H3K4me1 profiles and influences cell growth and gene expression

BACKGROUND: The histone 3 lysine 4 (H3K4) monomethylase KMT2C is mutated across several cancer types; however, the effects of mutations on epigenome organization, gene expression, and cell growth are not clear. A frequently recurring mutation in colorectal cancer (CRC) with microsatellite instabilit...

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Detalles Bibliográficos
Autores principales:	Larsson, Chatarina, Cordeddu, Lina, Siggens, Lee, Pandzic, Tatjana, Kundu, Snehangshu, He, Liqun, Ali, Muhammad Akhtar, Pristovšek, Nuša, Hartman, Karin, Ekwall, Karl, Sjöblom, Tobias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257146/ https://www.ncbi.nlm.nih.gov/pubmed/32471474 http://dx.doi.org/10.1186/s13148-020-00863-z

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