Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review

Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol (DAG) generated in the different cellular compartments in various physiological processes. DAG accumulates in multiple organs of the obese subjects, which leads to the disruption of metabolic homeostasis and the deve...

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Autores principales: Kolczynska, Katarzyna, Loza-Valdes, Angel, Hawro, Izabela, Sumara, Grzegorz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257441/
https://www.ncbi.nlm.nih.gov/pubmed/32466765
http://dx.doi.org/10.1186/s12944-020-01286-8
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author Kolczynska, Katarzyna
Loza-Valdes, Angel
Hawro, Izabela
Sumara, Grzegorz
author_facet Kolczynska, Katarzyna
Loza-Valdes, Angel
Hawro, Izabela
Sumara, Grzegorz
author_sort Kolczynska, Katarzyna
collection PubMed
description Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol (DAG) generated in the different cellular compartments in various physiological processes. DAG accumulates in multiple organs of the obese subjects, which leads to the disruption of metabolic homeostasis and the development of diabetes as well as associated diseases. Multiple studies proved that aberrant activation of PKCs and PKDs contributes to the development of metabolic diseases. DAG-sensing PKC and PKD isoforms play a crucial role in the regulation of metabolic homeostasis and therefore might serve as targets for the treatment of metabolic disorders such as obesity and diabetes.
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spelling pubmed-72574412020-06-07 Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review Kolczynska, Katarzyna Loza-Valdes, Angel Hawro, Izabela Sumara, Grzegorz Lipids Health Dis Review Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol (DAG) generated in the different cellular compartments in various physiological processes. DAG accumulates in multiple organs of the obese subjects, which leads to the disruption of metabolic homeostasis and the development of diabetes as well as associated diseases. Multiple studies proved that aberrant activation of PKCs and PKDs contributes to the development of metabolic diseases. DAG-sensing PKC and PKD isoforms play a crucial role in the regulation of metabolic homeostasis and therefore might serve as targets for the treatment of metabolic disorders such as obesity and diabetes. BioMed Central 2020-05-28 /pmc/articles/PMC7257441/ /pubmed/32466765 http://dx.doi.org/10.1186/s12944-020-01286-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Kolczynska, Katarzyna
Loza-Valdes, Angel
Hawro, Izabela
Sumara, Grzegorz
Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review
title Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review
title_full Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review
title_fullStr Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review
title_full_unstemmed Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review
title_short Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review
title_sort diacylglycerol-evoked activation of pkc and pkd isoforms in regulation of glucose and lipid metabolism: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257441/
https://www.ncbi.nlm.nih.gov/pubmed/32466765
http://dx.doi.org/10.1186/s12944-020-01286-8
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