ZJ01, a Small Molecule Inhibitor of the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction, Reduces Hyperoxic Acute Lung Injury in a Mouse Model

BACKGROUND: Hyperoxic acute lung injury (ALI) is a complication of ventilation in patients with respiratory failure. Nuclear factor erythroid-2-related factor 2 (Nrf2) has an important role in ALI. Kelch-like ECH-associated protein 1 (Keap1) binds to Nrf2. ZJ01 is a small molecule inhibitor of Keap1...

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Detalles Bibliográficos
Autores principales: Wan, Jun, Lin, Shaoyan, Huang, Xiuling, Li, Qianqin, Zeng, Lingjun, Du, Songlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2020
Materias:
Animal Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257880/
https://www.ncbi.nlm.nih.gov/pubmed/32437336
http://dx.doi.org/10.12659/MSM.920467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257880/
https://www.ncbi.nlm.nih.gov/pubmed/32437336
http://dx.doi.org/10.12659/MSM.920467

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