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Long non-coding RNA MEG3 is involved in osteogenic differentiation and bone diseases (Review)

Osteogenic differentiation originating from mesenchymal stem cells (MSCs) requires tight co-ordination of transcriptional factors, signaling pathways and biomechanical cues. Dysregulation of such reciprocal networks may influence the proliferation and apoptosis of MSCs and osteoblasts, thereby impai...

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Autores principales: Sun, Hong, Peng, Guoxuan, Wu, Hongbin, Liu, Miao, Mao, Guping, Ning, Xu, Yang, Hua, Deng, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257936/
https://www.ncbi.nlm.nih.gov/pubmed/32494359
http://dx.doi.org/10.3892/br.2020.1305
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author Sun, Hong
Peng, Guoxuan
Wu, Hongbin
Liu, Miao
Mao, Guping
Ning, Xu
Yang, Hua
Deng, Jin
author_facet Sun, Hong
Peng, Guoxuan
Wu, Hongbin
Liu, Miao
Mao, Guping
Ning, Xu
Yang, Hua
Deng, Jin
author_sort Sun, Hong
collection PubMed
description Osteogenic differentiation originating from mesenchymal stem cells (MSCs) requires tight co-ordination of transcriptional factors, signaling pathways and biomechanical cues. Dysregulation of such reciprocal networks may influence the proliferation and apoptosis of MSCs and osteoblasts, thereby impairing bone metabolism and homeostasis. An increasing number of studies have shown that long non-coding (lnc)RNAs are involved in osteogenic differentiation and thus serve an important role in the initiation, development, and progression of bone diseases such as tumors, osteoarthritis and osteoporosis. It has been reported that the lncRNA, maternally expressed gene 3 (MEG3), regulates osteogenic differentiation of multiple MSCs and also acts as a critical mediator in the development of bone formation and associated diseases. In the present review, the proposed mechanisms underlying the roles of MEG3 in osteogenic differentiation and its potential effects on bone diseases are discussed. These discussions may help elucidate the roles of MEG3 in osteogenic differentiation and highlight potential biomarkers and therapeutic targets for the treatment of bone diseases.
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spelling pubmed-72579362020-06-02 Long non-coding RNA MEG3 is involved in osteogenic differentiation and bone diseases (Review) Sun, Hong Peng, Guoxuan Wu, Hongbin Liu, Miao Mao, Guping Ning, Xu Yang, Hua Deng, Jin Biomed Rep Review Osteogenic differentiation originating from mesenchymal stem cells (MSCs) requires tight co-ordination of transcriptional factors, signaling pathways and biomechanical cues. Dysregulation of such reciprocal networks may influence the proliferation and apoptosis of MSCs and osteoblasts, thereby impairing bone metabolism and homeostasis. An increasing number of studies have shown that long non-coding (lnc)RNAs are involved in osteogenic differentiation and thus serve an important role in the initiation, development, and progression of bone diseases such as tumors, osteoarthritis and osteoporosis. It has been reported that the lncRNA, maternally expressed gene 3 (MEG3), regulates osteogenic differentiation of multiple MSCs and also acts as a critical mediator in the development of bone formation and associated diseases. In the present review, the proposed mechanisms underlying the roles of MEG3 in osteogenic differentiation and its potential effects on bone diseases are discussed. These discussions may help elucidate the roles of MEG3 in osteogenic differentiation and highlight potential biomarkers and therapeutic targets for the treatment of bone diseases. D.A. Spandidos 2020-07 2020-05-15 /pmc/articles/PMC7257936/ /pubmed/32494359 http://dx.doi.org/10.3892/br.2020.1305 Text en Copyright: © Sun et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Sun, Hong
Peng, Guoxuan
Wu, Hongbin
Liu, Miao
Mao, Guping
Ning, Xu
Yang, Hua
Deng, Jin
Long non-coding RNA MEG3 is involved in osteogenic differentiation and bone diseases (Review)
title Long non-coding RNA MEG3 is involved in osteogenic differentiation and bone diseases (Review)
title_full Long non-coding RNA MEG3 is involved in osteogenic differentiation and bone diseases (Review)
title_fullStr Long non-coding RNA MEG3 is involved in osteogenic differentiation and bone diseases (Review)
title_full_unstemmed Long non-coding RNA MEG3 is involved in osteogenic differentiation and bone diseases (Review)
title_short Long non-coding RNA MEG3 is involved in osteogenic differentiation and bone diseases (Review)
title_sort long non-coding rna meg3 is involved in osteogenic differentiation and bone diseases (review)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257936/
https://www.ncbi.nlm.nih.gov/pubmed/32494359
http://dx.doi.org/10.3892/br.2020.1305
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