Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA) thereby limiting auto-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H(2)O(2)). We show that MAO metabolism of DA does not increase cytosolic H(2)O(2), but leads to mitochondrial electron transport chain (ETC) activ...

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Detalles Bibliográficos
Autores principales: Graves, Steven M., Xie, Zhong, Stout, Kristen A., Zampese, Enrico, Burbulla, Lena F., Shih, Jean C., Kondapalli, Jyothisri, Patriarchi, Tomasso, Tian, Lin, Brichta, Lars, Greengard, Paul, Krainc, Dimitri, Schumacker, Paul T., Surmeier, D. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257994/
https://www.ncbi.nlm.nih.gov/pubmed/31844313
http://dx.doi.org/10.1038/s41593-019-0556-3
Descripción
Sumario:Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA) thereby limiting auto-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H(2)O(2)). We show that MAO metabolism of DA does not increase cytosolic H(2)O(2), but leads to mitochondrial electron transport chain (ETC) activity. This was dependent upon MAO anchoring to the outer mitochondrial membrance and shuttling of electrons through the intermembrane space to support the bioenergetic demands of phasic DA release.

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