Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA) thereby limiting auto-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H(2)O(2)). We show that MAO metabolism of DA does not increase cytosolic H(2)O(2), but leads to mitochondrial electron transport chain (ETC) activ...

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Autores principales: Graves, Steven M., Xie, Zhong, Stout, Kristen A., Zampese, Enrico, Burbulla, Lena F., Shih, Jean C., Kondapalli, Jyothisri, Patriarchi, Tomasso, Tian, Lin, Brichta, Lars, Greengard, Paul, Krainc, Dimitri, Schumacker, Paul T., Surmeier, D. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257994/
https://www.ncbi.nlm.nih.gov/pubmed/31844313
http://dx.doi.org/10.1038/s41593-019-0556-3
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author Graves, Steven M.
Xie, Zhong
Stout, Kristen A.
Zampese, Enrico
Burbulla, Lena F.
Shih, Jean C.
Kondapalli, Jyothisri
Patriarchi, Tomasso
Tian, Lin
Brichta, Lars
Greengard, Paul
Krainc, Dimitri
Schumacker, Paul T.
Surmeier, D. James
author_facet Graves, Steven M.
Xie, Zhong
Stout, Kristen A.
Zampese, Enrico
Burbulla, Lena F.
Shih, Jean C.
Kondapalli, Jyothisri
Patriarchi, Tomasso
Tian, Lin
Brichta, Lars
Greengard, Paul
Krainc, Dimitri
Schumacker, Paul T.
Surmeier, D. James
author_sort Graves, Steven M.
collection PubMed
description Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA) thereby limiting auto-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H(2)O(2)). We show that MAO metabolism of DA does not increase cytosolic H(2)O(2), but leads to mitochondrial electron transport chain (ETC) activity. This was dependent upon MAO anchoring to the outer mitochondrial membrance and shuttling of electrons through the intermembrane space to support the bioenergetic demands of phasic DA release.
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spelling pubmed-72579942020-06-16 Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain Graves, Steven M. Xie, Zhong Stout, Kristen A. Zampese, Enrico Burbulla, Lena F. Shih, Jean C. Kondapalli, Jyothisri Patriarchi, Tomasso Tian, Lin Brichta, Lars Greengard, Paul Krainc, Dimitri Schumacker, Paul T. Surmeier, D. James Nat Neurosci Article Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA) thereby limiting auto-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H(2)O(2)). We show that MAO metabolism of DA does not increase cytosolic H(2)O(2), but leads to mitochondrial electron transport chain (ETC) activity. This was dependent upon MAO anchoring to the outer mitochondrial membrance and shuttling of electrons through the intermembrane space to support the bioenergetic demands of phasic DA release. 2019-12-16 2020-01 /pmc/articles/PMC7257994/ /pubmed/31844313 http://dx.doi.org/10.1038/s41593-019-0556-3 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Graves, Steven M.
Xie, Zhong
Stout, Kristen A.
Zampese, Enrico
Burbulla, Lena F.
Shih, Jean C.
Kondapalli, Jyothisri
Patriarchi, Tomasso
Tian, Lin
Brichta, Lars
Greengard, Paul
Krainc, Dimitri
Schumacker, Paul T.
Surmeier, D. James
Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain
title Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain
title_full Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain
title_fullStr Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain
title_full_unstemmed Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain
title_short Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain
title_sort dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257994/
https://www.ncbi.nlm.nih.gov/pubmed/31844313
http://dx.doi.org/10.1038/s41593-019-0556-3
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