Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France

We report the discovery of a new orthobunyavirus, Cristoli virus, by means of shotgun metagenomics. The virus was identified in an immunodepressed patient with fatal encephalitis. Full-length genome sequencing revealed high-level expression of a virulence factor, possibly explaining the severity of...

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Autores principales: Rodriguez, Christophe, Gricourt, Guillaume, Ndebi, Melissa, Demontant, Vanessa, Poiteau, Lila, Burrel, Sonia, Boutolleau, David, Woerther, Paul-Louis, Calvez, Vincent, Stroer, Sebastian, Pawlotsky, Jean-Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2020
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7258463/
https://www.ncbi.nlm.nih.gov/pubmed/32441621
http://dx.doi.org/10.3201/eid2606.191431
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author Rodriguez, Christophe
Gricourt, Guillaume
Ndebi, Melissa
Demontant, Vanessa
Poiteau, Lila
Burrel, Sonia
Boutolleau, David
Woerther, Paul-Louis
Calvez, Vincent
Stroer, Sebastian
Pawlotsky, Jean-Michel
author_facet Rodriguez, Christophe
Gricourt, Guillaume
Ndebi, Melissa
Demontant, Vanessa
Poiteau, Lila
Burrel, Sonia
Boutolleau, David
Woerther, Paul-Louis
Calvez, Vincent
Stroer, Sebastian
Pawlotsky, Jean-Michel
author_sort Rodriguez, Christophe
collection PubMed
description We report the discovery of a new orthobunyavirus, Cristoli virus, by means of shotgun metagenomics. The virus was identified in an immunodepressed patient with fatal encephalitis. Full-length genome sequencing revealed high-level expression of a virulence factor, possibly explaining the severity of the infection. The patient’s recent history suggests circulation in France.
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spelling pubmed-72584632020-06-09 Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France Rodriguez, Christophe Gricourt, Guillaume Ndebi, Melissa Demontant, Vanessa Poiteau, Lila Burrel, Sonia Boutolleau, David Woerther, Paul-Louis Calvez, Vincent Stroer, Sebastian Pawlotsky, Jean-Michel Emerg Infect Dis Dispatch We report the discovery of a new orthobunyavirus, Cristoli virus, by means of shotgun metagenomics. The virus was identified in an immunodepressed patient with fatal encephalitis. Full-length genome sequencing revealed high-level expression of a virulence factor, possibly explaining the severity of the infection. The patient’s recent history suggests circulation in France. Centers for Disease Control and Prevention 2020-06 /pmc/articles/PMC7258463/ /pubmed/32441621 http://dx.doi.org/10.3201/eid2606.191431 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Rodriguez, Christophe
Gricourt, Guillaume
Ndebi, Melissa
Demontant, Vanessa
Poiteau, Lila
Burrel, Sonia
Boutolleau, David
Woerther, Paul-Louis
Calvez, Vincent
Stroer, Sebastian
Pawlotsky, Jean-Michel
Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France
title Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France
title_full Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France
title_fullStr Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France
title_full_unstemmed Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France
title_short Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France
title_sort fatal encephalitis caused by cristoli virus, an emerging orthobunyavirus, france
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7258463/
https://www.ncbi.nlm.nih.gov/pubmed/32441621
http://dx.doi.org/10.3201/eid2606.191431
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