Global perspectives on primary immune deficiency diseases

Poverty, mass migration, live vaccines, inbred marriage, exotic dishes, contaminated water, natural disasters and the next pandemic, they may all affect your patient with a congenital immune defect. In this chapter, we discuss some interesting aspects and regional differences in the field of Primary immune deficiencies: from climate change and emerging infectious diseases, to the geopolitics of gene discovery and blood trade, passing through consanguinity, founder effects, transfer factor, vaccination, medical curricula, and what the future may bring. We live on a changing, shrinking planet, and we believe we all need to know about customs, infections, and unique aspects in other regions of the world.