SARS-CoV-2 entry in host cells-multiple targets for treatment and prevention

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new viral disease that has gained global attention owing to its ability to provoke community and health-care-associated outbreaks of severe infections in human populations. The virus poses serious challenges to clinical management bec...

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Detalles Bibliográficos
Autores principales: Mahmoud, Ismail Sami, Jarrar, Yazun Bashir, Alshaer, Walhan, Ismail, Said
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7258854/
https://www.ncbi.nlm.nih.gov/pubmed/32479856
http://dx.doi.org/10.1016/j.biochi.2020.05.012
Descripción
Sumario:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new viral disease that has gained global attention owing to its ability to provoke community and health-care-associated outbreaks of severe infections in human populations. The virus poses serious challenges to clinical management because there are still no approved anti- SARS-CoV-2 drugs available. In this mini-review, we summarize the much updated published reports that demonstrate the mechanism of SARS-CoV-2 entry into host cells, and discuss the availability and development of attractive host-based therapeutic options for SARS-CoV-2 infections.

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