SARS-CoV-2 entry in host cells-multiple targets for treatment and prevention

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new viral disease that has gained global attention owing to its ability to provoke community and health-care-associated outbreaks of severe infections in human populations. The virus poses serious challenges to clinical management bec...

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Autores principales: Mahmoud, Ismail Sami, Jarrar, Yazun Bashir, Alshaer, Walhan, Ismail, Said
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7258854/
https://www.ncbi.nlm.nih.gov/pubmed/32479856
http://dx.doi.org/10.1016/j.biochi.2020.05.012
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author Mahmoud, Ismail Sami
Jarrar, Yazun Bashir
Alshaer, Walhan
Ismail, Said
author_facet Mahmoud, Ismail Sami
Jarrar, Yazun Bashir
Alshaer, Walhan
Ismail, Said
author_sort Mahmoud, Ismail Sami
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new viral disease that has gained global attention owing to its ability to provoke community and health-care-associated outbreaks of severe infections in human populations. The virus poses serious challenges to clinical management because there are still no approved anti- SARS-CoV-2 drugs available. In this mini-review, we summarize the much updated published reports that demonstrate the mechanism of SARS-CoV-2 entry into host cells, and discuss the availability and development of attractive host-based therapeutic options for SARS-CoV-2 infections.
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spelling pubmed-72588542020-05-29 SARS-CoV-2 entry in host cells-multiple targets for treatment and prevention Mahmoud, Ismail Sami Jarrar, Yazun Bashir Alshaer, Walhan Ismail, Said Biochimie Article Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new viral disease that has gained global attention owing to its ability to provoke community and health-care-associated outbreaks of severe infections in human populations. The virus poses serious challenges to clinical management because there are still no approved anti- SARS-CoV-2 drugs available. In this mini-review, we summarize the much updated published reports that demonstrate the mechanism of SARS-CoV-2 entry into host cells, and discuss the availability and development of attractive host-based therapeutic options for SARS-CoV-2 infections. Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). 2020-08 2020-05-29 /pmc/articles/PMC7258854/ /pubmed/32479856 http://dx.doi.org/10.1016/j.biochi.2020.05.012 Text en © 2020 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Mahmoud, Ismail Sami
Jarrar, Yazun Bashir
Alshaer, Walhan
Ismail, Said
SARS-CoV-2 entry in host cells-multiple targets for treatment and prevention
title SARS-CoV-2 entry in host cells-multiple targets for treatment and prevention
title_full SARS-CoV-2 entry in host cells-multiple targets for treatment and prevention
title_fullStr SARS-CoV-2 entry in host cells-multiple targets for treatment and prevention
title_full_unstemmed SARS-CoV-2 entry in host cells-multiple targets for treatment and prevention
title_short SARS-CoV-2 entry in host cells-multiple targets for treatment and prevention
title_sort sars-cov-2 entry in host cells-multiple targets for treatment and prevention
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7258854/
https://www.ncbi.nlm.nih.gov/pubmed/32479856
http://dx.doi.org/10.1016/j.biochi.2020.05.012
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