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Metformin inhibits testosterone-induced endoplasmic reticulum stress in ovarian granulosa cells via inactivation of p38 MAPK

STUDY QUESTION: Does metformin inhibit excessive androgen-induced endoplasmic reticulum (ER) stress in mouse granulosa cells (GCs) in vivo and in vitro? SUMMARY ANSWER: Metformin inhibits testosterone-induced ER stress and unfolded protein response (UPR) activation by suppressing p38 MAPK phosphoryl...

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Detalles Bibliográficos
Autores principales:	Jin, Jiamin, Ma, Yerong, Tong, Xiaomei, Yang, Weijie, Dai, Yongdong, Pan, Yibin, Ren, Peipei, Liu, Liu, Fan, Heng-Yu, Zhang, Yinli, Zhang, Songying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259369/ https://www.ncbi.nlm.nih.gov/pubmed/32372097 http://dx.doi.org/10.1093/humrep/deaa077

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