Cargando…

Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline

BACKGROUND: Alzheimer’s disease (AD) pathology precedes symptoms and its detection can identify at-risk individuals who may benefit from early treatment. Since the retinal nerve fiber layer (RNFL) is depleted in established AD, we tested whether its thickness can predict whether cognitively healthy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Asanad, Samuel, Fantini, Michele, Sultan, William, Nassisi, Marco, Felix, Christian M., Wu, Jessica, Karanjia, Rustum, Ross-Cisneros, Fred N., Sagare, Abhay P., Zlokovic, Berislav V., Chui, Helena C., Pogoda, Janice M., Arakaki, Xianghong, Fonteh, Alfred N., Sadun A. A., Alfredo A., Harrington, Michael G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259639/ https://www.ncbi.nlm.nih.gov/pubmed/32469871 http://dx.doi.org/10.1371/journal.pone.0232785

Ejemplares similares

Correction: Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline
por: Asanad, Samuel, et al.
Publicado: (2020)

Evidence that blood–CSF barrier transport, but not inflammatory biomarkers, change in migraine, while CSF sVCAM1 associates with migraine frequency and CSF fibrinogen
por: Cowan, Robert P., et al.
Publicado: (2021)

The retinal choroid as an oculovascular biomarker for Alzheimer's dementia: A histopathological study in severe disease
por: Asanad, Samuel, et al.
Publicado: (2019)

The Retina in Alzheimer's Disease: Histomorphometric Analysis of an Ophthalmologic Biomarker
por: Asanad, Samuel, et al.
Publicado: (2019)

Hormone replacement therapy in Leber's hereditary optic neuropathy: Accelerated visual recovery in vivo
por: Fantini, Michele, et al.
Publicado: (2018)

Retinal ganglion cell dysfunction in preclinical Alzheimer’s disease: an electrophysiologic biomarker signature
por: Asanad, Samuel, et al.
Publicado: (2021)

Compromised Behavior and Gamma Power During Working Memory in Cognitively Healthy Individuals With Abnormal CSF Amyloid/Tau
por: Rochart, Roger, et al.
Publicado: (2020)

Value of medical history in ophthalmology: A study of diagnostic accuracy
por: Wang, Michelle Y., et al.
Publicado: (2018)

Improving the visual outcome in Leber's hereditary optic neuropathy: Framework for the future
por: Asanad, Samuel, et al.
Publicado: (2019)

Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease
por: Sweeney, Melanie D, et al.
Publicado: (2015)

Severe Headache or Migraine History Is Inversely Correlated With Dietary Sodium Intake: NHANES 1999–2004
por: Pogoda, Janice M., et al.
Publicado: (2016)

Task switching reveals abnormal brain-heart electrophysiological signatures in cognitively healthy individuals with abnormal CSF amyloid/tau, a pilot study
por: Arechavala, Rebecca Johnson, et al.
Publicado: (2021)

Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer’s disease: the role, regulation and restoration of LRP1
por: Ramanathan, Anita, et al.
Publicado: (2015)

Pupillometry evaluation of melanopsin retinal ganglion cell function and sleep-wake activity in pre-symptomatic Alzheimer’s disease
por: Oh, Angela J., et al.
Publicado: (2019)

Correction: Pupillometry evaluation of melanopsin retinal ganglion cell function and sleep-wake activity in pre-symptomatic Alzheimer’s disease
por: Oh, Angela J., et al.
Publicado: (2020)

Alpha desynchronization/synchronization during working memory testing is compromised in acute mild traumatic brain injury (mTBI)
por: Arakaki, Xianghong, et al.
Publicado: (2018)

Brain barriers and their potential role in migraine pathophysiology
por: Wiggers, Astrid, et al.
Publicado: (2022)

Endogenous Na(+), K(+)-ATPase inhibitors and CSF [Na(+)] contribute to migraine formation
por: Gross, Noah B., et al.
Publicado: (2019)

3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice
por: Lazic, Divna, et al.
Publicado: (2019)

Pericyte loss influences Alzheimer-like neurodegeneration in mice
por: Sagare, Abhay P., et al.
Publicado: (2013)

Author Correction: Pericyte loss influences Alzheimer-like neurodegeneration in mice
por: Sagare, Abhay P., et al.
Publicado: (2023)

A Female Patient with Down Syndrome and Low-Penetrance Leber's Hereditary Optic Neuropathy
por: Frousiakis, Starleen E., et al.
Publicado: (2014)

Human Cerebrospinal Fluid Fatty Acid Levels Differ between Supernatant Fluid and Brain-Derived Nanoparticle Fractions, and Are Altered in Alzheimer's Disease
por: Fonteh, Alfred N., et al.
Publicado: (2014)

Alpha desynchronization during simple working memory unmasks pathological aging in cognitively healthy individuals
por: Arakaki, Xianghong, et al.
Publicado: (2019)

Functional connectivity among brain regions affected in Alzheimer’s disease is associated with CSF TNF-α in APOE4 carriers
por: Contreras, Joey Annette, et al.
Publicado: (2019)

Sphingolipid Metabolism Correlates with Cerebrospinal Fluid Beta Amyloid Levels in Alzheimer’s Disease
por: Fonteh, Alfred N., et al.
Publicado: (2015)

Accumulation of Cerebrospinal Fluid Glycerophospholipids and Sphingolipids in Cognitively Healthy Participants With Alzheimer’s Biomarkers Precedes Lipolysis in the Dementia Stage
por: Fonteh, Alfred N., et al.
Publicado: (2020)

Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo
por: Nelson, Amy R., et al.
Publicado: (2020)

Lipid Metabolism in Late-Onset Alzheimer’s Disease Differs from Patients Presenting with Other Dementia Phenotypes
por: Sarrafpour, Syena, et al.
Publicado: (2019)

Decreased functional connectivity is associated with increased levels of Cerebral Spinal Fluid soluble-PDGFRβ, a marker of blood brain barrier breakdown, in older adults
por: Contreras, Joey Annette, et al.
Publicado: (2023)

Leber's hereditary optic neuropathy: Shifting our attention to the macula
por: Asanad, Samuel, et al.
Publicado: (2018)

Phospholipase C activity increases in cerebrospinal fluid from migraineurs in proportion to the number of comorbid conditions: a case–control study
por: Fonteh, Alfred N, et al.
Publicado: (2013)

Polyunsaturated Fatty Acid Composition of Cerebrospinal Fluid Fractions Shows Their Contribution to Cognitive Resilience of a Pre-symptomatic Alzheimer’s Disease Cohort
por: Fonteh, Alfred N., et al.
Publicado: (2020)

Urine dicarboxylic acids change in pre-symptomatic Alzheimer’s disease and reflect loss of energy capacity and hippocampal volume
por: Castor, K. J., et al.
Publicado: (2020)

Angioarchitectural Evolution of Clival Dural Arteriovenous Fistulas in Two Patients
por: Pouw, Andrew E., et al.
Publicado: (2015)

Benefit of Stimulus Size V Perimetry for Patients With a Dense Central Scotoma From Leber's Hereditary Optic Neuropathy
por: Mejia-Vergara, Alvaro J., et al.
Publicado: (2021)

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism
por: Ma, Qingyi, et al.
Publicado: (2018)

Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism
por: Ma, Qingyi, et al.
Publicado: (2022)

Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C
por: Huuskonen, Mikko T., et al.
Publicado: (2021)

Correction: Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier
por: Kisler, Kassandra, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_7htlq04uimjesnkthnokpc80qr