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Ex vivo lung CT findings may predict the outcome of the early phase after lung transplantation

PURPOSE: We developed an ex vivo lung CT (EVL-CT) technique that allows us to obtain detailed CT images and morphologically assess the retrieved lung from a donor for transplantation. After we recovered the lung graft from a brain-dead donor, we transported it to our hospital and CT images were obta...

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Autores principales: Oishi, Hisashi, Noda, Masafumi, Sado, Tetsu, Matsuda, Yasushi, Niikawa, Hiromichi, Watanabe, Tatsuaki, Sakurada, Akira, Hoshikawa, Yasushi, Okada, Yoshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259648/
https://www.ncbi.nlm.nih.gov/pubmed/32469995
http://dx.doi.org/10.1371/journal.pone.0233804
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author Oishi, Hisashi
Noda, Masafumi
Sado, Tetsu
Matsuda, Yasushi
Niikawa, Hiromichi
Watanabe, Tatsuaki
Sakurada, Akira
Hoshikawa, Yasushi
Okada, Yoshinori
author_facet Oishi, Hisashi
Noda, Masafumi
Sado, Tetsu
Matsuda, Yasushi
Niikawa, Hiromichi
Watanabe, Tatsuaki
Sakurada, Akira
Hoshikawa, Yasushi
Okada, Yoshinori
author_sort Oishi, Hisashi
collection PubMed
description PURPOSE: We developed an ex vivo lung CT (EVL-CT) technique that allows us to obtain detailed CT images and morphologically assess the retrieved lung from a donor for transplantation. After we recovered the lung graft from a brain-dead donor, we transported it to our hospital and CT images were obtained ex vivo before lung transplant surgery. The objective of this study was to investigate the correlation between the EVL-CT findings and post-transplant outcome in patients who underwent bilateral lung transplantation (BLT) or single lung transplantation (SLT). METHODS: We retrospectively reviewed the records of 70 patients with available EVL-CT data who underwent BLT (34 cases) or SLT (36 cases) in our hospital between October 2007 and September 2017. The recipients were divided into 2 groups (control group, infiltration group) according to the findings of EVL-CT of the lung graft in BLT and SLT, respectively. Recipients in the control group were transplanted lung grafts without any infiltrates (BLT control group, SLT control group). Recipients in the infiltration group received lung grafts with infiltrates (BLT infiltration group, SLT infiltration group). RESULTS: The recipients in the BLT infiltration group showed significantly slower recovery from primary graft dysfunction and a longer mechanical ventilation period and ICU stay period than those in the BLT control group. The mechanical ventilation period was significantly longer in the recipients in the SLT infiltration group than those in the SLT control group. CONCLUSION: EVL-CT may predict the outcome of the early phase after lung transplantation.
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spelling pubmed-72596482020-06-08 Ex vivo lung CT findings may predict the outcome of the early phase after lung transplantation Oishi, Hisashi Noda, Masafumi Sado, Tetsu Matsuda, Yasushi Niikawa, Hiromichi Watanabe, Tatsuaki Sakurada, Akira Hoshikawa, Yasushi Okada, Yoshinori PLoS One Research Article PURPOSE: We developed an ex vivo lung CT (EVL-CT) technique that allows us to obtain detailed CT images and morphologically assess the retrieved lung from a donor for transplantation. After we recovered the lung graft from a brain-dead donor, we transported it to our hospital and CT images were obtained ex vivo before lung transplant surgery. The objective of this study was to investigate the correlation between the EVL-CT findings and post-transplant outcome in patients who underwent bilateral lung transplantation (BLT) or single lung transplantation (SLT). METHODS: We retrospectively reviewed the records of 70 patients with available EVL-CT data who underwent BLT (34 cases) or SLT (36 cases) in our hospital between October 2007 and September 2017. The recipients were divided into 2 groups (control group, infiltration group) according to the findings of EVL-CT of the lung graft in BLT and SLT, respectively. Recipients in the control group were transplanted lung grafts without any infiltrates (BLT control group, SLT control group). Recipients in the infiltration group received lung grafts with infiltrates (BLT infiltration group, SLT infiltration group). RESULTS: The recipients in the BLT infiltration group showed significantly slower recovery from primary graft dysfunction and a longer mechanical ventilation period and ICU stay period than those in the BLT control group. The mechanical ventilation period was significantly longer in the recipients in the SLT infiltration group than those in the SLT control group. CONCLUSION: EVL-CT may predict the outcome of the early phase after lung transplantation. Public Library of Science 2020-05-29 /pmc/articles/PMC7259648/ /pubmed/32469995 http://dx.doi.org/10.1371/journal.pone.0233804 Text en © 2020 Oishi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Oishi, Hisashi
Noda, Masafumi
Sado, Tetsu
Matsuda, Yasushi
Niikawa, Hiromichi
Watanabe, Tatsuaki
Sakurada, Akira
Hoshikawa, Yasushi
Okada, Yoshinori
Ex vivo lung CT findings may predict the outcome of the early phase after lung transplantation
title Ex vivo lung CT findings may predict the outcome of the early phase after lung transplantation
title_full Ex vivo lung CT findings may predict the outcome of the early phase after lung transplantation
title_fullStr Ex vivo lung CT findings may predict the outcome of the early phase after lung transplantation
title_full_unstemmed Ex vivo lung CT findings may predict the outcome of the early phase after lung transplantation
title_short Ex vivo lung CT findings may predict the outcome of the early phase after lung transplantation
title_sort ex vivo lung ct findings may predict the outcome of the early phase after lung transplantation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259648/
https://www.ncbi.nlm.nih.gov/pubmed/32469995
http://dx.doi.org/10.1371/journal.pone.0233804
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