Gut microbial diversity, inflammation, and oxidative stress are associated with tacrolimus dosing requirements early after heart transplantation

INTRODUCTION: Effective tacrolimus (TAC) dosing is hampered by complex pharmacokinetics and significant patient variability. The gut microbiome, a key mediator of endotoxemia, inflammation and oxidative stress in advanced heart failure (HF) patients, is a possible contributor to interindividual vari...

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Detalles Bibliográficos
Autores principales: Jennings, Douglas L., Bohn, Bruno, Zuver, Amelia, Onat, Duygu, Gaine, Maureen, Royzman, Eugene, Hupf, Jonathan, Brunjes, Danielle, Latif, Farhana, Restaino, Susan, Garan, Arthur R., Topkara, Veli K., Takayama, Hiroo, Takeda, Koji, Naka, Yoshifumi, Farr, Maryjane, Nandakumar, Renu, Uhlemann, Anne-Catrin, Colombo, Paolo C., Demmer, Ryan T., Yuzefpolskaya, Melana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259664/
https://www.ncbi.nlm.nih.gov/pubmed/32469966
http://dx.doi.org/10.1371/journal.pone.0233646

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