S. aureus alpha-toxin monomer binding and heptamer formation in host cell membranes – Do they determine sensitivity of airway epithelial cells toward the toxin?

Alpha-toxin (Hla) is a major virulence factor of Staphylococcus aureus (S. aureus) and plays an important role in S. aureus-induced pneumonia. It binds as a monomer to the cell surface of eukaryotic host cells and forms heptameric transmembrane pores. Sensitivities toward the toxin of various types...

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Detalles Bibliográficos
Autores principales: Möller, Nils, Ziesemer, Sabine, Hildebrandt, Petra, Assenheimer, Nadine, Völker, Uwe, Hildebrandt, Jan-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259691/
https://www.ncbi.nlm.nih.gov/pubmed/32470006
http://dx.doi.org/10.1371/journal.pone.0233854

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