An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications

Agents that modulate pre-mRNA splicing are of interest in multiple therapeutic areas, including cancer. We report our recent screening results with the application of a cell-based Triple Exon Skipping Luciferase Reporter (TESLR) using a library that is composed of FDA approved drugs, clinical compou...

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Detalles Bibliográficos
Autores principales: Shi, Yihui, Bray, Walter, Smith, Alexander J., Zhou, Wei, Calaoagan, Joy, Lagisetti, Chandraiah, Sambucetti, Lidia, Crews, Phillip, Lokey, R. Scott, Webb, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259758/
https://www.ncbi.nlm.nih.gov/pubmed/32469945
http://dx.doi.org/10.1371/journal.pone.0233672

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259758/
https://www.ncbi.nlm.nih.gov/pubmed/32469945
http://dx.doi.org/10.1371/journal.pone.0233672

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