Cargando…

An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications

Agents that modulate pre-mRNA splicing are of interest in multiple therapeutic areas, including cancer. We report our recent screening results with the application of a cell-based Triple Exon Skipping Luciferase Reporter (TESLR) using a library that is composed of FDA approved drugs, clinical compou...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Yihui, Bray, Walter, Smith, Alexander J., Zhou, Wei, Calaoagan, Joy, Lagisetti, Chandraiah, Sambucetti, Lidia, Crews, Phillip, Lokey, R. Scott, Webb, Thomas R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259758/ https://www.ncbi.nlm.nih.gov/pubmed/32469945 http://dx.doi.org/10.1371/journal.pone.0233672

Ejemplares similares

Pharmacodynamic assays to facilitate preclinical and clinical development of pre-mRNA splicing modulatory drug candidates
por: Shi, Yihui, et al.
Publicado: (2015)

Prediction of alternatively skipped exons and splicing enhancers from exon junction arrays
por: Kechris, Katerina, et al.
Publicado: (2008)

The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia
por: Xargay-Torrent, Sílvia, et al.
Publicado: (2015)

Quality control of MATa1 splicing and exon skipping by nuclear RNA degradation
por: Egecioglu, Defne E., et al.
Publicado: (2012)

ExonSkipDB: functional annotation of exon skipping event in human
por: Kim, Pora, et al.
Publicado: (2020)

Endogenous Multiple Exon Skipping and Back-Splicing at the DMD Mutation Hotspot
por: Suzuki, Hitoshi, et al.
Publicado: (2016)

Splicing Factor 3B Subunit 1 Interacts with HIV Tat and Plays a Role in Viral Transcription and Reactivation from Latency
por: Kyei, George B., et al.
Publicado: (2018)

Exon skipping for DMD
por: Aartsma-Rus, Annemieke, et al.
Publicado: (2012)

CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion
por: Mou, Haiwei, et al.
Publicado: (2017)

Reverse complementary matches simultaneously promote both back-splicing and exon-skipping
por: Cao, Dong
Publicado: (2021)

Differential Splicing of Skipped Exons Predicts Drug Response in Cancer Cell Lines
por: Simpson, Edward, et al.
Publicado: (2021)

Natural Exon Skipping Sets the Stage for Exon Skipping as Therapy for Dystrophic Epidermolysis Bullosa
por: Bremer, Jeroen, et al.
Publicado: (2019)

Exon-Skipping in Duchenne Muscular Dystrophy
por: Takeda, Shin’ichi, et al.
Publicado: (2021)

Therapeutic exon skipping for dysferlinopathies?
por: Aartsma-Rus, Annemieke, et al.
Publicado: (2010)

Thousands of exon skipping events differentiate among splicing patterns in sixteen human tissues
por: Florea, Liliana, et al.
Publicado: (2013)

Dynamic ASXL1 Exon Skipping and Alternative Circular Splicing in Single Human Cells
por: Koh, Winston, et al.
Publicado: (2016)

Activation of Cryptic 3′ Splice-Sites by SRSF2 Contributes to Cassette Exon Skipping
por: Moon, Heegyum, et al.
Publicado: (2019)

Sudemycin E influences alternative splicing and changes chromatin modifications
por: Convertini, Paolo, et al.
Publicado: (2014)

Computational analysis reveals a correlation of exon-skipping events with splicing, transcription and epigenetic factors
por: Ye, Zhenqing, et al.
Publicado: (2014)

Dystrophin rescue by trans-splicing: a strategy for DMD genotypes not eligible for exon skipping approaches
por: Lorain, Stéphanie, et al.
Publicado: (2013)

Shorter Phosphorodiamidate Morpholino Splice-Switching Oligonucleotides May Increase Exon-Skipping Efficacy in DMD
por: Akpulat, Ugur, et al.
Publicado: (2018)

BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance
por: Nesic, Ksenija, et al.
Publicado: (2023)

Targeted Exon Skipping to Correct Exon Duplications in the Dystrophin Gene
por: Greer, Kane L, et al.
Publicado: (2014)

APC Splicing Mutations Leading to In-Frame Exon 12 or Exon 13 Skipping Are Rare Events in FAP Pathogenesis and Define the Clinical Outcome
por: Disciglio, Vittoria, et al.
Publicado: (2021)

The Effect of 6-Thioguanine on Alternative Splicing and Antisense-Mediated Exon Skipping Treatment for Duchenne Muscular Dystrophy
por: Verhaart, Ingrid E. C., et al.
Publicado: (2012)

Nonsequential Splicing Events Alter Antisense-Mediated Exon Skipping Outcome in COL7A1
por: Ham, Kristin A., et al.
Publicado: (2020)

Targeted SMN Exon Skipping: A Useful Control to Assess In Vitro and In Vivo Splice-Switching Studies
por: Flynn, Loren L., et al.
Publicado: (2021)

Exon-skipping antisense oligonucleotides for cystic fibrosis therapy
por: Kim, Young Jin, et al.
Publicado: (2022)

Insecticide resistance mediated by an exon skipping event
por: Berger, Madeleine, et al.
Publicado: (2016)

Therapeutic Prospects of Exon Skipping for Epidermolysis Bullosa
por: Vermeer, Franciscus C., et al.
Publicado: (2021)

Variants Affecting Exon Skipping Contribute to Complex Traits
por: Lee, Younghee, et al.
Publicado: (2012)

Skipping of Exons by Premature Termination of Transcription and Alternative Splicing within Intron-5 of the Sheep SCF Gene: A Novel Splice Variant
por: Saravanaperumal, Siva Arumugam, et al.
Publicado: (2012)

A novel splice mutation induces exon skipping of the EXT1 gene in patients with hereditary multiple exostoses
por: Guo, Xiaoyan, et al.
Publicado: (2019)

Classifying Included and Excluded Exons in Exon Skipping Event Using Histone Modifications
por: Chen, Wei, et al.
Publicado: (2018)

A Genotype-Phenotype Correlation Study of Exon Skip-Equivalent In-Frame Deletions and Exon Skip-Amenable Out-of-Frame Deletions across the DMD Gene to Simulate the Effects of Exon-Skipping Therapies: A Meta-Analysis
por: Anwar, Saeed, et al.
Publicado: (2021)

Targeted exon skipping of NF1 exon 17 as a therapeutic for neurofibromatosis type I
por: Leier, André, et al.
Publicado: (2022)

Elevated nuclear TDP-43 induces constitutive exon skipping
por: Carmen-Orozco, Rogger P., et al.
Publicado: (2023)

Multiple exon skipping strategies to by-pass dystrophin mutations
por: Adkin, Carl F., et al.
Publicado: (2012)

Elusive sources of variability of dystrophin rescue by exon skipping
por: Vila, Maria Candida, et al.
Publicado: (2015)

Skipping Multiple Exons to Treat DMD—Promises and Challenges
por: Aslesh, Tejal, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_oh7l6nl12cr5tpl1ok8cu9gous