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Lung aeration in experimental malaria-associated acute respiratory distress syndrome by SPECT/CT analysis
Malaria-associated acute respiratory distress syndrome (ARDS) is an inflammatory disease causing alveolar-pulmonary barrier lesion and increased vascular permeability characterized by severe hypoxemia. Computed tomography (CT), among other imaging techniques, allows the morphological and quantitativ...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259762/ https://www.ncbi.nlm.nih.gov/pubmed/32470082 http://dx.doi.org/10.1371/journal.pone.0233864 |
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author | Quirino, Thatyane de Castro Ortolan, Luana dos Santos Sercundes, Michelle Klein Marinho, Claudio Romero Farias Turato, Walter Miguel Epiphanio, Sabrina |
author_facet | Quirino, Thatyane de Castro Ortolan, Luana dos Santos Sercundes, Michelle Klein Marinho, Claudio Romero Farias Turato, Walter Miguel Epiphanio, Sabrina |
author_sort | Quirino, Thatyane de Castro |
collection | PubMed |
description | Malaria-associated acute respiratory distress syndrome (ARDS) is an inflammatory disease causing alveolar-pulmonary barrier lesion and increased vascular permeability characterized by severe hypoxemia. Computed tomography (CT), among other imaging techniques, allows the morphological and quantitative identification of lung lesions during ARDS. This study aims to identify the onset of malaria-associated ARDS development in an experimental model by imaging diagnosis. Our results demonstrated that ARDS-developing mice presented decreased gaseous exchange and pulmonary insufficiency, as shown by the SPECT/CT technique. The pulmonary aeration disturbance in ARDS-developing mice on the 5(th) day post infection was characterized by aerated tissues decrease and nonaerated tissue accumulation, demonstrating increased vascular permeability and pleural effusion. The SPECT/CT technique allowed the early diagnosis in the experimental model, as well as the identification of the pulmonary aeration. Notwithstanding, despite the fact that this study contributes to better understand lung lesions during malaria-associated ARDS, further imaging studies are needed. |
format | Online Article Text |
id | pubmed-7259762 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-72597622020-06-08 Lung aeration in experimental malaria-associated acute respiratory distress syndrome by SPECT/CT analysis Quirino, Thatyane de Castro Ortolan, Luana dos Santos Sercundes, Michelle Klein Marinho, Claudio Romero Farias Turato, Walter Miguel Epiphanio, Sabrina PLoS One Research Article Malaria-associated acute respiratory distress syndrome (ARDS) is an inflammatory disease causing alveolar-pulmonary barrier lesion and increased vascular permeability characterized by severe hypoxemia. Computed tomography (CT), among other imaging techniques, allows the morphological and quantitative identification of lung lesions during ARDS. This study aims to identify the onset of malaria-associated ARDS development in an experimental model by imaging diagnosis. Our results demonstrated that ARDS-developing mice presented decreased gaseous exchange and pulmonary insufficiency, as shown by the SPECT/CT technique. The pulmonary aeration disturbance in ARDS-developing mice on the 5(th) day post infection was characterized by aerated tissues decrease and nonaerated tissue accumulation, demonstrating increased vascular permeability and pleural effusion. The SPECT/CT technique allowed the early diagnosis in the experimental model, as well as the identification of the pulmonary aeration. Notwithstanding, despite the fact that this study contributes to better understand lung lesions during malaria-associated ARDS, further imaging studies are needed. Public Library of Science 2020-05-29 /pmc/articles/PMC7259762/ /pubmed/32470082 http://dx.doi.org/10.1371/journal.pone.0233864 Text en © 2020 Quirino et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Quirino, Thatyane de Castro Ortolan, Luana dos Santos Sercundes, Michelle Klein Marinho, Claudio Romero Farias Turato, Walter Miguel Epiphanio, Sabrina Lung aeration in experimental malaria-associated acute respiratory distress syndrome by SPECT/CT analysis |
title | Lung aeration in experimental malaria-associated acute respiratory distress syndrome by SPECT/CT analysis |
title_full | Lung aeration in experimental malaria-associated acute respiratory distress syndrome by SPECT/CT analysis |
title_fullStr | Lung aeration in experimental malaria-associated acute respiratory distress syndrome by SPECT/CT analysis |
title_full_unstemmed | Lung aeration in experimental malaria-associated acute respiratory distress syndrome by SPECT/CT analysis |
title_short | Lung aeration in experimental malaria-associated acute respiratory distress syndrome by SPECT/CT analysis |
title_sort | lung aeration in experimental malaria-associated acute respiratory distress syndrome by spect/ct analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259762/ https://www.ncbi.nlm.nih.gov/pubmed/32470082 http://dx.doi.org/10.1371/journal.pone.0233864 |
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