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Alternative splicing of jnk1a in zebrafish determines first heart field ventricular cardiomyocyte numbers through modulation of hand2 expression

The planar cell polarity pathway is required for heart development and whilst the functions of most pathway members are known, the roles of the jnk genes in cardiac morphogenesis remain unknown as mouse mutants exhibit functional redundancy, with early embryonic lethality of compound mutants. In thi...

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Detalles Bibliográficos
Autores principales: Santos-Ledo, Adrian, Washer, Sam, Dhanaseelan, Tamil, Eley, Lorraine, Alqatani, Ahlam, Chrystal, Paul W., Papoutsi, Tania, Henderson, Deborah J., Chaudhry, Bill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259801/
https://www.ncbi.nlm.nih.gov/pubmed/32421721
http://dx.doi.org/10.1371/journal.pgen.1008782